Clinical efficacy analysis of picosecond laser combined with traditional Chinese medicine mask in the treatment of melasma

doi:10.3969/j.issn.1006-7795.2023.05.020

Abstract

Abstract: Objective To analyze the efficacy and safety of 755 nm picosecond laser combined with traditional Chinese medicine mask in the treatment of melasma.Methods Adult female patients with melasma were recruited prospectively and randomly divided into observation group and control group. The observation group received one picosecond laser treatment every 4 weeks, three times at 0, 4 and 8 week, and applied the self-made Chinese medicine facial mask twice a week for 12 weeks. The control group received only three picosecond laser treatments. The score statistics of modified Melasma Area and Severity Index (mMASI) were performed before the first laser treatment (0 week), the second laser treatment (4 week), the last laser treatment (8 week), the fourth week after the last laser treatment (12 week), the eighth week after the last laser treatment (16 week), and the twelfth week after the last laser treatment (20 week). At 12 week, the Physician Global Assessment (PGA) score, effective rate and patient satisfaction were evaluated, and adverse reactions were recorded during treatment.Results A total of 40 patients were included, including 20 patients in the observation group and 20 patients in the control group. Totally 17 patients in the observation group and 20 patients in the control group completed the whole treatment and follow-up. After treatment, melasma in the observation group and the control group improved to varying degrees. The mMASI scores in the observation group at 0, 4, 8, 12, 16 and 20 week were 6.14±1.97, 5.05±2.01, 4.44±1.79, 3.41±2.45, 2.66±1.94, 2.33±1.99 and in the control group were 7.33±2.85, 6.74±2.84, 5.96±2.39, 5.01±2.27, 4.48±2.39, 4.31±2.37. The results of two-way repeated-measures ANOVA showed that there was a statistically significant difference in mMASI scores between observation time points (P time<0.05). The mMASI scores at each observation time point were lower in the observation group than those in the control group, and the differences between groups were statistically significant (P group<0.05). There was no interaction between intervention measures and time (P>0.05). There was no statistically significant difference in the distribution of PGA scores or patient satisfaction between the two groups (P>0.05). There were no obvious side effects in both groups.Conclusions 755 nm picosecond laser combined with traditional Chinese medicine mask is safe and effective in the treatment of melasma, and patients have good treatment experience.

Key words: melasma, picosecond laser, traditional Chinese medicine mask

CLC Number:

Shang Shuai, Liang Surong, Zhang Wensi, Tan Ansheng, Mei Xueling. Clinical efficacy analysis of picosecond laser combined with traditional Chinese medicine mask in the treatment of melasma[J]. Journal of Capital Medical University, 2023, 44(5): 845-851.

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