Primary Evaluation of the Efficacy and Safety of Standardized Dust Mite Allergen Vaccine in the Treatment of Allergic Rhinitis

Journal of Capital Medical University ›› 2005, Vol. 26 ›› Issue (3): 246-248.

• 专题报道 • Previous Articles Next Articles

Primary Evaluation of the Efficacy and Safety of Standardized Dust Mite Allergen Vaccine in the Treatment of Allergic Rhinitis

Wang Chengshuo¹, Zhang Luo^1,2, Han Demin^1,2

1. Beijing Institute of Otolaryngology;2. Department of Otorhinolaryngology-Head and Neck Surgery, Beijing Tongren Hospital, Capital University of Medical Sciences

Received:2005-05-19 Revised:1900-01-01 Online:2005-06-24 Published:2005-06-24

Abstract

Abstract: Objective To evaluate the efficacy and safety of the standardized dust mites vaccine for the treatment of allergic rhinitis. Methods Thirty patients with allergic rhinitis caused by house-dust mites (HDM) were selected in this self-contrast study. Clinical efficacy was evaluated by symptom and sign score after six months of specific immunotherapy and compared with pre-treatment scores. Results Twenty eight patients completed the study. A clinically significant reduction in symptom and sign score in these 28 patients comparing with that of pre-treatment was founded, and the difference was significant(P<0.01). 92 local adverse reactions and 8 systemic reactions had occurred in total 566 injections, and no fatal systemic reaction occurred. Conclusion Standardized allergen specific immunotherapy is an effective treatment in patients suffering from allergic rhinitis due to house-dust mites.

Key words: dust mite, allergen vaccine, allergic rhinitis, specific immunotherapy

CLC Number:

R765.21

Wang Chengshuo;Zhang Luo;Han Demin;. Primary Evaluation of the Efficacy and Safety of Standardized Dust Mite Allergen Vaccine in the Treatment of Allergic Rhinitis[J]. Journal of Capital Medical University, 2005, 26(3): 246-248.

[1]	Zhang Peng, Yang Wei, Wang Kuiji, Tan Yi, Shang Xiaojuan, Shu Ning, Wang Xiang, Xu Shiwen, Sun Sanfeng, Zhao Xinyu, Yu Kun, Chen Luquan. A multi-center prospective case series study on the treatment of allergic rhinitis by acupuncture of sphenopalatine ganglion [J]. Journal of Capital Medical University, 2019, 40(6): 916-920.
[2]	Xu Qingqing, Duan Su, Wang Xiangdong, Zhang Luo. Meta-analysis of the effect of the correction of deviation of the nasal septum in patients with allergic rhinitis [J]. Journal of Capital Medical University, 2018, 39(6): 928-932.
[3]	Gao Zhanmei, Song Yang, Liu Hua, Wen Changlong, Sun Haiyang. Rapeutic effect of azelastine nasal spray combined with desloratadine in the treatment of allergic rhinitis: a system review and Meta-analysis [J]. Journal of Capital Medical University, 2018, 39(3): 458-464.
[4]	Li Jingyun, Zhang Yuan, Zhang Luo. Association between single nucleotide polymorphisms in NOS2 gene and house dust mite-sensitive allergic rhinitis [J]. Journal of Capital Medical University, 2018, 39(1): 51-56.
[5]	Yang Jun, Wang Min, Zhang Luo. Expression of cytokines and immunoglobulin antibodies in the early asymptomatic and late symptomatic stage of allergic rhinitis mouse model [J]. Journal of Capital Medical University, 2018, 39(1): 63-68.
[6]	Zheng Kaili, Wang Xiangdong, Zhang Luo. Research progress of NADPH oxidase in inflammatory diseases of respiratory tract [J]. Journal of Capital Medical University, 2018, 39(1): 69-73.
[7]	Lou Hongfei, Ma Siyuan, Zhao Yan, Cao Feifei, He Fei, Wang Xiangdong, Wang Chengshuo, Zhang Luo. Sensitization patterns for aeroallergens in self-reported allergic rhinitis within Beijing, Tianjin, and Hebei region [J]. Journal of Capital Medical University, 2017, 38(5): 665-670.
[8]	Ma Siyuan, Lou Hongfei, Wang Chengshuo, Zhang Luo. Characteristic analysis of aeroallergens in Beijing patients suspicious of allergic rhinitis [J]. Journal of Capital Medical University, 2017, 38(5): 671-676.
[9]	Zhao Yanming, Wang Chengshuo, Zhao Yali, Zhang Yuan, Zhang Luo. Association between human leukocyte antigenⅡ (HLA-Ⅱ) gene polymorphism and house dust mites-sensitive allergic rhinitis in Chinese subjects [J]. Journal of Capital Medical University, 2017, 38(5): 688-694.
[10]	Zhao Yali, Zhang Yuan, Wang Chengshuo, Zhang Luo. Non-synonymous variant rs2228145 in interleukin-6 receptor (IL-6R) gene is associated with allergic rhinitis in Chinese subjects [J]. Journal of Capital Medical University, 2017, 38(5): 695-699.
[11]	Huang Huijie, Liu Xiaoying, Hou Xiaoling, Miao Qing, Xiang Li. Effects of dust mite allergy immunotherapy on clinical efficacy and airway hyperresponsiveness in allergic asthma and rhinitis children sensitized to dust mite [J]. Journal of Capital Medical University, 2016, 37(5): 568-573.
[12]	WANG Min, YANG Jun, SHANG Jun, ZHANG Luo. Expression of tumor necrosis factor-α-inducible protein-2 in a mouse model of allergic rhinitis and its relationship with angiogenesis [J]. Journal of Capital Medical University, 2013, 34(6): 790-794.
[13]	ZHAO Yanming, ZHANG Luo. Progress in genetic study on allergic rhinitis [J]. Journal of Capital Medical University, 2013, 34(6): 808-813.
[14]	OUYANG Yuhui;Zhang Deshan;ZHAO Liping;ZHANG Luo. Correlation between the counting results of Durham pollen sampler and automatically pollen monitor [J]. Journal of Capital Medical University, 2012, 33(6): 713-716.
[15]	LOU Wei;WANG Chengshuo;ZHANG Luo. Role of regulatory T cells in the allergic rhinitis and allergen-specific immunotherapy [J]. Journal of Capital Medical University, 2012, 33(6): 729-734.

Primary Evaluation of the Efficacy and Safety of Standardized Dust Mite Allergen Vaccine in the Treatment of Allergic Rhinitis

PDF

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments