Abstract: Objective To explore the changes of high sensitive c-reactive protein(hs-CRP) in patients with acute coronary syndrome(ACS) and the variation tendency of hs-CRP in acute myocardial infraction(AMI) patients. Methods The single-centre study enrolled 126 acute myocardial infraction(AMI) patients and 135 unstable angina(UA) patients. The serum hs-CRP were measured by immune nephelometry. Leucocyte neutrophilic granulocyte and serum lipids(TC, LDL-C, HDL-C and TG) were also be measured. In 22 AMI patients, hs-CRP was measured at within 12 h, 24 h, 48 h, 72 h and 7 d. Results The levels of hs-CRP in patients with AMI(6.26±5.60 mg/ L ) were significantly higher than those in UA patients(3.52±4.34 mg/L)(P=0.000). The levels of leucocyte and neutrophilic granulocyte in AMI group were significantly higher than those in UA patients. There was no significant difference of the serum lipids(TC, LDL-C, HDL-C and TG) between the two groups(P>0.05). The levels of hs-CRP at 48 h or 72 h in AMI patients were significantly higher than those within 12 h. Conclusion The levels of hs-CRP in AMI patients are higher than those in UA patients. The levels of hs-CRP at 48 h or 72 h in AMI patients are superior to those within 12 h in reflecting the severity of AMI.

Key words: high sensitive c-reactive protein, acute coronary syndrome, acute myocardial infarction, unstable angina