Abstract: Objective To summarize the clinical data of premature ovarian failure(PDF) and evaluate the efficacy of hormone replacement therapy(HRT) of premature ovarian failure patients to explore the treatment of premature ovarian failure. Methods From January 2000 to January 2008, 38 cases of premature ovarian failure were enrolled in clinical data analysis, and were treated with the HRT for 3 months to 1 year to observe the changes in clinical symptoms, pelvic ultrasound, serum reproductive hormone levels, blood lipids and liver and kidney function after HRT. Results In 25 cases the clinical symptoms were eased by HRT significantly , the cure rate was 13.2%, and the effective rate was 65.8%. Compared with pre-medication, serum follicle stimulating hormone(FSH) levels decreased significantly(P<0.01), serum luteinizing hormone(LH) level decreased significantly(P<0.05). Both ovarian volume had no significant change(P>0.05), marked thickening of the endometrium(P<0.01) was noted. Neither damage to the liver and kidney function nor other side effects were found during the medication. Conclusion Premature ovarian failure is a disease caused by multiple factors, and its treatment is difficult. Hormone replacement therapy can alleviate clinical symptoms, reduce serum FSH, LH significantly, and can prevent complications.

Key words: premature ovarian failure, hormone replacement treatment, sex hormone