The progress in apoptotic mechanism of ovarian granulosa cells involved in premature ovarian failure

doi:10.3969/j.issn.1006-7795.2014.03.023

Abstract

Abstract:

Premature ovarian failure(POF), with an increasingly higher and higher incidence, has become a serious disease which threatens female health in recent years. Many scholars have studied the etiology of it and found that the cause of this disease is multifaceted: genetic defects, hormone and its receptor defects, metabolic disorders and autoimmune disorders can all account for this disease. In addition, some artificial mechanical damage can also induce POF, but the exact mechanism is still unknown. No matter what cause above is the culprit, apoptosis of the granulosa cells concomitantly is widespread in the study, which shows it showed a direct relationship with POF. In this paper, current research progress of granulosa cells' apoptosis in POF will be reviewed and a mechanism of granulosa cells' apoptosis causing POF will be proposed, which aims to provide a reference for future research.

Key words: premature ovarian failure, apoptosis, ovarian granulosa cells, granulosa cells, immune regulation

CLC Number:

R271.11

Ye Na, Dong Xiaoying, Li Donghua. The progress in apoptotic mechanism of ovarian granulosa cells involved in premature ovarian failure[J]. Journal of Capital Medical University, 2014, 35(3): 379-383.

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URL: https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/10.3969/j.issn.1006-7795.2014.03.023

https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/Y2014/V35/I3/379

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