Abstract: Objective To investigate the efficacy and related influence factors and side effects of different antiviral drugs.Methods Retrospective study was performed,10489 patients who were diagnosed chronic hepatitis B in the following hospitals(Beijing You'an Hospital,the First Hospital,Beijing University,The No.302 Hospital of the People Liberation Army and Beijing Ditan Hospital) and treated with antiviral drugs from 1995 to 2002,were followed.Antiviral efficacy of the four drugs and related factors were compared.Results 1) Forty percent of the patients were treated with antiviral drugs,which were higher than other regions in China.2) Of all the four drugs,interferon and lamivudine had better efficacy than the other drugs.Lamivudine can suppress HBV DNA effectively,but after stoping treatment,the HBV DNA level rebounded.The serum conversion rate of HBeAg/HbeAb was very low(13.3%).Interferon group was much better(22.9%) and lasted for long time although the side effects were more than other groups.3) Statistics showed that the patients with the high ALT and low HBV DNA level before treatment had better response to antiviral treatment.4) Most of the patients and doctors recognized the side effects,but glucose,hypothyroid function,auto-antibodies were not tested in about half of the patients.Conclusion Because of the limited effects of single antiviral drugs,it is very necessary to carry out prospective research to investigate more effective antiviral methods and the predicted factors to improve the prognosis of hepatitis.At the same time,we should pay much alternation to the side effects to ensure the treatment safety.

Key words: chronic hepatitis B, antiviral treatment, interferon, lamivudine