Abstract: Objective To study the clinical characteristics, the pathological features, and the expression patterns of MDR1 and GFAPin intractable epilepsy patients with varied etiologies and to analyze the relations between clinical and pathological performances among those cases.Methods The clinical characteristics of strictly selected 26 intractable epilepsy patients were conduded and the pathological changes including the expression of MDR1 and GFAPfrom surgically resected tissues were analyzed systematically observed under light and electron microscopy.The relations between the clinical and pathological manifestutions of each subject were studied.Results There were certain common clinical characteristics, such as the onset of age and main types of seizure, which could be concluded in all studied cases, although the etiology of each subject may vary.Meanwhile some pathological changes including neuronal degeneration, reactive proliferation of astrocyte with over expression of GFAPand MDR1 appeared as the common features among all cases.Conclusion There are common pathological characteristics in the patients with intractable epilepsy, although the etiologies of them may vary.It may be resulted from recurrent epileptic ictus.

Key words: human intractable epilepsy, clinical characteristics, pathological characteristics, expression of MDR1 and GFAP