Effects of RGDS Peptide on Aggregation and Phosphorylation of ERK1/2 in Rat Platelets in Vitro

Abstract

Abstract:

Objective To obsere influence of RGDS peptide on rat platelet aggregation rate and the ERK1/2 phosphorylation induced by different agonists in vivo and study the relationship between the change of ERK1/2 phosphorylation and the change of platelets aggregation with RGDS peptide. Methods Maximal aggregation rate(MAR) was measured with nephelometry; ERK1/2 phosphorylation was detected by Western blot. Results The MAR and phosphorylation of ERK1/2 were inhibited by RGDS peptide. Conclusion The phosphorylation of ERK1/2 was one of the cellular signal transduction mechanisms of the platelets aggregation; and the inhibition of ERK1/2 phosphorylation of may be one of the mechanisms that RGDS peptide antagonize thrombus.

Key words: ERK1/2, platelets aggregation, RGDS peptide, cellular signal transduction

CLC Number:

R543

Zhang Like;Liu Yuling;Lu Lingqiao;Yao Xinghai. Effects of RGDS Peptide on Aggregation and Phosphorylation of ERK1/2 in Rat Platelets in Vitro[J]. Journal of Capital Medical University, 2005, 26(3): 291-292.

[1]	Xu Jianke, Liu Ning, Han Miao, Zhang Hongyang, Han Xinsheng. Analysis of the relationship between non-high-density lipoprotein cholesterol and arterial plaque characteristic in a cohort of ischemic stroke patients [J]. Journal of Capital Medical University, 2023, 44(1): 49-53.
[2]	Ning Bin, Zhang Dong, Wang Lishu, Jin Jin, Gan Yuyang, Song Haiman, Yu Tengfei, He Wen. A study on the diversity ultrasonographic manifestations of carotid web: compared with histopathology [J]. Journal of Capital Medical University, 2019, 40(6): 824-828.
[3]	Pan Lili, Du Juan, Ren Yanlong, Liu Wenxian. Clinical manifestation in Takayasu arteritis patients with history of tuberculosis [J]. Journal of Capital Medical University, 2019, 40(4): 621-626.
[4]	Qi Xianmei, Wang Lei, Zhang Ruiheng, Liu Ting, Liu Jie, Yang Ting, Wang Jun, Zhang Zhifei, Wang Chen. Rapeutic effect of MCC950 on monocrotaline induced rat pulmonary arterial hypertension and mechanism [J]. Journal of Capital Medical University, 2018, 39(6): 871-876.
[5]	Xu Qing, Liu Lina, Song Yanting, Qu Aijuan. Assessing stiffness of carotid artery via two-dimensional speckle-tracking in mice [J]. Journal of Capital Medical University, 2018, 39(6): 883-888.
[6]	Li Shuang, Wang Wei, Hong Hui, Zhao Lu, Wang yanling. Relationship between branch retinal vein occlusion and internal carotid artery elasticity [J]. Journal of Capital Medical University, 2017, 38(1): 6-10.
[7]	Zhang Xin, Liu Yuan, Ge Jianli, Song Yihua, Ma Yunlong, Li Xiaodong. Experimental study of Qi Huang Ju Yu Fang on rat limb arterial occlusive disease [J]. Journal of Capital Medical University, 2016, 37(3): 352-355.
[8]	Wang Dezhao, Ma Ning, Hu Hongyu, Mo Dapeng, Fu Qiang, Chen Wei, Jiang Guiying, Miao Zhongrong, Chen Buxing. Relationship between the lesions of coronary artery and the upper-aortic arteries stenosis [J]. Journal of Capital Medical University, 2016, 37(1): 58-61.
[9]	Xu Fengbo, Sun Yi, Wang Yinna, Cheng Hao. Analysis of related factors of coronary artery calcification in maintenance hemodialysis patients [J]. Journal of Capital Medical University, 2015, 36(4): 630-633.
[10]	Peng Xiaole, Wang Xiaolong, Liu Yuyong, Gong Ming, Li Haiyang, Guan Xinliang, Guo Dong, Huang Qi, Zhang Hongjia. Effects of temperature gradient classification on perioperative cerebral protection in Stanford A aortic dissection [J]. Journal of Capital Medical University, 2015, 36(3): 364-370.
[11]	Yao Peng, Pan Xudong, Qiao Huanyu, Liu Ningning, Xue Jinrong, Bai Tao, Liu Yongmin. Anatomic data and clinical significance of aortic arch with type A aortic dissection in China: single center experience [J]. Journal of Capital Medical University, 2015, 36(3): 354-359.
[12]	Zhao Hui, Zhang Fuxian, Li Hailei, Zhang huan. Design of a new biodegradable vena cava filter [J]. Journal of Capital Medical University, 2015, 36(1): 28-33.
[13]	Wei Zhanyun, Hua Qi. Relationship between red cell distribution width and high-sensitivity C-reactive protein in acute coronary syndrome of elderly patients [J]. Journal of Capital Medical University, 2015, 36(1): 63-66.
[14]	Li Boyu, Hua Qi, Li Jing, Shao Qiang, Chu Yanyan. Analysis of the effect of possible influential factors on renal function among patients 1 year after coronary interventions [J]. Journal of Capital Medical University, 2015, 36(1): 58-62.
[15]	Zhang Pengrui, Xu Yuan, Wang Guang, Yang Jinkui. Non-high density lipoprotein-cholesterol is an indicator to assess cardiovascular risk for subjects with dyslipidemia [J]. Journal of Capital Medical University, 2014, 35(1): 73-76.

Effects of RGDS Peptide on Aggregation and Phosphorylation of ERK1/2 in Rat Platelets in Vitro

PDF

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments