Abstract:

Objective To observe the effects of CoCl₂ treatment on tolerance of mice to hypoxia. Methods Balb/c mice were injected with CoCl₂ 3 h before exposure to hypoxia. The animals' tolerance time of each hypoxia exposure and the disappearance time of wave PS of hippocampal slice were recorded. Results The hypoxic tolerance time of CoCl₂ pretreated mice was increased but unchanged during the repetitive exposure to hypoxia, whereas the tolerance time of control group was increased as the exposure to hypoxia increased. The disappearance time of wave PS of hippocampal slice in CoCl₂ administrated group was longer than that of control but shorter than hypoxic preconditioning group. Conclusion Different molecular mechanisms are thought to be involved in the induction of tolerance to hypoxia between hypoxic preconditioned and CoCl₂ treated mice.

Key words: mice, CoCl₂, hippocampus slice, population spike