Antioxidant activity of lycopene-curcumin combination in mice with acute ethanol oxidative damage

doi:10.3969/j.issn.1006-7795.2021.01.015

Abstract

Abstract: Objective To evaluate the antioxidant effect of lycopene combined with curcumin on mice with acute alcoholism. Methods Healthy male Kunming mice were divided into 5 groups according to the weight, respectively for the blank control group, model control group, the low, medium and high three level doses subjects’ intervention group (100, 200, 600 mg/kg). The mice were given subjects through gavage administration for 30 consecutive days. On the 31st day of the experiment, the model control group and three level groups were administrated 50% anhydrous ethanol (12 mL/kg) by gavage after a 16 h overnight fasting, and the blank group was not processed. Blood was collected from the inner canthus of mice after 6 h. Those indexes were determined including the total superoxide dismutase (T-SOD) activity, protein carbonyl (PC), reduced glutathione (GSH), glutathione peroxidase activities (GSH-Px), malondialdehyde (MDA) and in blood samples of mice. Results The activities of SOD and GSH-Px, content of GSH in the high-dose group mice were higher than those in the model control group (P<0.05), and the PC content of mice in the high-dose group was lower than that in the model control group (P<0.05). Conclusion The combined application of lycopene and curcumin has potential antioxidant effects. Pretreatment with the combinations of lycopene and curcumin effectively attenuated the oxidative damage caused by acute alcoholic injury mice.

Key words: lycopene, curcumin, antioxidant, mice

CLC Number:

Gao Lifang, Gao Wen. Antioxidant activity of lycopene-curcumin combination in mice with acute ethanol oxidative damage[J]. Journal of Capital Medical University, 2021, 42(1): 89-93.

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URL: https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/10.3969/j.issn.1006-7795.2021.01.015

https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/Y2021/V42/I1/89

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