Effect of Manganese on Mitochondria Membrane Potential of Different-aged Rats in Vitro

Journal of Capital Medical University ›› 2004, Vol. 25 ›› Issue (4): 424-426.

• 论著·基础研究 • Previous Articles Next Articles

Effect of Manganese on Mitochondria Membrane Potential of Different-aged Rats in Vitro

Zhang Shuhua¹, Chu Jinhua¹, Xuan Dengfeng¹, Wu Ping¹, Li Guojun¹, Geng Rong², Guo Wenrui²

1. College of Public Health and Family Medicine, Capital University of Medical Sciences;2. Beijing Fengtai Center of Disease Control and Prevention

Received:2004-02-16 Revised:1900-01-01 Online:2004-10-15 Published:2004-10-15

Abstract

Abstract: The aim was to study the effect of Mn 2+ exposure on membrane function of different month rats brain mitochondrial. Different-aged (4 months and 18 months) Wistar rats's mitochondria were extracted, exposed to MnCl₂·4H₂O and then divided into five groups(50, 100, 200, 400 μmol/L and the control group). The fluorescence intensity was detected in successive 3 min by fluorophotometric method. Compared with the control group' the exposed groups showed obvious reduction(P<0.05). In addtion, there was significant difference among the drug-receiving groups(P<0.05). Function and resistance of mitochondrial membrane are decreased with the increase of dosage andages.

Key words: manganese, mitochondria, membrane potential

CLC Number:

R135.1

Zhang Shuhua;Chu Jinhua;Xuan Dengfeng;Wu Ping;Li Guojun;Geng Rong;Guo Wenrui. Effect of Manganese on Mitochondria Membrane Potential of Different-aged Rats in Vitro[J]. Journal of Capital Medical University, 2004, 25(4): 424-426.

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Effect of Manganese on Mitochondria Membrane Potential of Different-aged Rats in Vitro

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