Expression of Cytokine Induced Neutrophil Chemoattractant in Lung Tissue of Rats with Acute Pancreatitis

Journal of Capital Medical University ›› 2005, Vol. 26 ›› Issue (6): 737-740.

• 临床研究 • Previous Articles Next Articles

Expression of Cytokine Induced Neutrophil Chemoattractant in Lung Tissue of Rats with Acute Pancreatitis

Lin Dongdong¹, Sun Jiabang², Li Fei², Zhang Shuwen², Cui Yeqing², Liu Dachuan², Zhu Bin², Sun Haichen², Liu Shuang²

1. Department of Hepatobiliary Surgery, Beijing Youan Hospital, Capital University of Medical Sciences;2. Department of General Surgery, Xuanwu Hospital, Capital University of Medical Sciences

Received:2004-11-18 Revised:1900-01-01 Online:2005-12-24 Published:2005-12-24

Abstract

Abstract: Objective To explore the role of cytokine induced neutrophil chemoattractant(CINC) in pathogenesis of acute pancreatitis-associated acute lung injury(PALI) in rats.Methods Pancreatitis was induced with 3.5% sodium taurocholate.The severity of pancreatitis was evaluated by quantitation serum lipase and pancreatic pathologic score.Lung injury was evaluated by lung pathologic score and lung water content.RT-PCR(reverse transcription polymerase chain reaction) analysis was performed to assess gene expression of CINCin lung tissue.Results Lung injury can be found at 1 h after induction of pancreatitis with 3.5% sodium taurocholate.Lung water content increased from 4 h after induction of pancreatitis.The expression of CINCmRNAin lung tissue increased markedly 1 h after induction of pancreatitis, and gradually reached its peak after 24 h.Conclusion CINCmay be involved in the pathogenesis of PALI.Inhibition of leukocytes chemotaxis in lung tissue may be a new way for the treatment of PALI.

Key words: acute pancreatitis, animal model, acute lung injury, chemokine

CLC Number:

R657.5

Lin Dongdong;Sun Jiabang;Li Fei;Zhang Shuwen;Cui Yeqing;Liu Dachuan;Zhu Bin;Sun Haichen;Liu Shuang. Expression of Cytokine Induced Neutrophil Chemoattractant in Lung Tissue of Rats with Acute Pancreatitis[J]. Journal of Capital Medical University, 2005, 26(6): 737-740.

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Expression of Cytokine Induced Neutrophil Chemoattractant in Lung Tissue of Rats with Acute Pancreatitis

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