Abstract:

Objective To investigate whether cytochrome P450 2C19(CYP2C19) /P450 2D6(CYP2D6) genetic polymorphisms were associated with schizophrenia in Chinese subjects. Methods 88 schizophrenics meeting criteria ICO-10 were enrolled in the study group and 283 healthy volunteers were involved in the control group. Polymerase chain reaction(PCR) and DNA sequencing were used to examine the CYP2C19(CYP2C192/CYP2C193 ). Use the same methods to detect CYP2D6(C100T) genetic polymorphisms of 87 schizophrenics meeting criteria ICO-10 and 93 healthy volunteers. The patients and healthy volunteers were divided into three groups accoding to the CYP2C192(G681A) genotypes(G/G, G/A, A/A), the same as CYP2C193(G636A) and CYP2D6(C100T). Results Six different allelic variants of CYP2C19 gene were observed in the control group and seven different allelic variants of CYP2C19 gene were detected in the schizophrenia group. There is no statistically significant difference in the allele frequencies of CYP2C192(χ²=4.954, P>0.05)and CYP2C193(χ²=2.334, P>0.05) between schizophrenia and healthy volunteers. We found the frequency of the homozygote of CYP2C192 in schizophrenia was conspicuously higher than that of healthy volunteers, There is no significant difference between two groups in CYP2D6(C100T) genotypes and alleles. Conclusion Although there is no evidence to show the correlation between CYP2C19/CYP2D6(C100T) genetic polymorphisms and etiology of schizophrenia, the homozygote of CYP2C192 is possible a genetic susceptibility factor in Chinese subjects with schizophrenia.

Key words: schizophrenia, CYP2C19, CYP2D6, genetic polymorphism