Expressions of NHERF1, PTEN and ERα protein in breast cancer and their clinical significance

doi:10.3969/j.issn.1006-7795.2012.06.017

Journal of Capital Medical University ›› 2012, Vol. 33 ›› Issue (6): 788-792.doi: 10.3969/j.issn.1006-7795.2012.06.017

• 基础研究 • Previous Articles Next Articles

Expressions of NHERF1, PTEN and ERα protein in breast cancer and their clinical significance

LI Yang¹, LI Yang¹, CHENG Shan¹, GE Zhicheng², SI Yang¹, HE Junqi¹

1. Department of Biochemistry and Molecular Biology, School of Basic Medical Science, Capital Medical University, Beijing 100069, China;2. Department of General Surgery, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China

Received:2012-09-19 Revised:1900-01-01 Online:2012-12-21 Published:2012-12-21

Abstract

Abstract: Objective To explore the expression and analyze the relationship among NHERF1, PTEN and ERα in breast cancer. Methods Immunohistochemical(S-P) method was used to evaluate NHERF1, PTEN and ERα protein expression in breast cancer and adjacent tissues. Results The expressions of NHERF1 and PTEN were very weak in the breast cancer tissues compared to their expressions at adjacent tissues(P<0.01). In contrast, the expressions of ERα was significantly higher in the adjacent tissues(P<0.01). Conclusion The expression of NHERF1 may regulate the PTEN expression in breast cancer. ERα plays an important role in the carcinogenesis and progression of breast cancer.

Key words: breast cancer, Na⁺/H⁺ exchanger regulatory factor 1, phosphatase and tensin homology deleted on chromosometen, estrogen receptor, immunohistochemistry

CLC Number:

R737.9

LI Yang;LI Yang;CHENG Shan;GE Zhicheng;SI Yang;HE Junqi. Expressions of NHERF1, PTEN and ERα protein in breast cancer and their clinical significance[J]. Journal of Capital Medical University, 2012, 33(6): 788-792.

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URL: https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/10.3969/j.issn.1006-7795.2012.06.017

https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/Y2012/V33/I6/788

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Expressions of NHERF1, PTEN and ERα protein in breast cancer and their clinical significance

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