A Meta-analysis on the effects of regimen XELOX versus FOLFOXs for treatment of Chinese patients with metastatic gastric cancer

doi:10.3969/j.issn.1006-7795.2013.03.019

Abstract

Abstract:

Objective Fluoropyrimidine combined with oxaliplatin were often used to treat the metastasis gastric cancer. In this paper, the clinical outcome and adverse reactions will be compared between the regimens XELOX and FOLFOXs for chemotherapy of metastasis gastric cancer in Chinese population.Methods The original articles on randomized controlled trials (RCTs) comparing the chemotherapy of XELOX and FOLFOXs in Chinese patients with advanced gastric cancer were recruited from the PubMed, Wanfang, VIP, and CNKI databases. The quality of the selected trials was assessed by Jadad-scale method. All eligible individuals were Chinese patients who had locally advanced or metastatic gastric cancer. Meta-analysis about the efficacy and safety of the two chemotherapy methods was performed by using Revman 5.0 and Stata 10.0 software. Egger's test was used to evaluate the publication bias. Results Thirteen RCT reports, including 783 Chinese patients with advanced gastric cancer, were recruited in this study based on the selected standard. The overall response rate was 53.52% in the XELOX treatment group which included 398 patients and 45.71% in FOLFOXs group which included 385 patients; respectively (OR=1.18, 95%CI: 1.02-1.35, P=0.03). For the safety evaluation, the nausea and vomiting incidence in XELOX treatment group possessed a higher rate than in FOLFOXs group (P<0.05). But the incidence of hand-foot syndrome was lower in FOLFOXs treatment group (P<0.05). The adverse reactions such as leukopenia, anemia, thrombocytopenia, peripheral nerve injury, and stomatitis did not exhibit any significant differences between the two groups (P>0.05). The Egger's test reveled that no significant publication bias was found (P=0.993). Conclusion In the chemotherapy of advanced or metastatic gastric cancer, the clinical response rate of XELOX was higher and the incidence of adverse reactions was slightly lower compared to FOLFOXs in Chinese patients.

Key words: gastric cancer, XELOX, FOLFOXs, Meta analysis

CLC Number:

R 730.5

ZHANG Ruixue, YAN Han, WANG Min, JIN Qicheng, YANG Yifan, CAO Bangwei. A Meta-analysis on the effects of regimen XELOX versus FOLFOXs for treatment of Chinese patients with metastatic gastric cancer[J]. Journal of Capital Medical University, 2013, 34(3): 422-427.

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URL: https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/10.3969/j.issn.1006-7795.2013.03.019

https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/Y2013/V34/I3/422

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