Development of progesterone receptor membrane component 1(PGRMC1) on the risk of breast cancer

doi:10.3969/j.issn.1006-7795.2013.04.004

Abstract

Abstract:

Breast cancer is one of the leading causes of death in women, and there is an urgent need for new biomarkers and therapeutic targets. In WHI study, estrogen therapy alone didn't increase the risk of breast cancer, but even reduced it. Continuous combined hormone therapy increased the breast cancer risk. The results showed that progestin has negative impact on the risk of breast cancer. Many experimental studies have showed that some synthetic progesterone can stimuliate the proliferation of MCF7/PGRMC1 breast cancer cells, So whether the increased breast cancer risk in WHI continuous combined arm could be explained by PGRMC1? whether PGRMC1 be developed as a potential marker for breast cancer susceptibility during HRT? We will review the results of related researches.

Key words: progesterone receptor membrane components, breast cancer, progesterone, estrogen

CLC Number:

R737.9

ZHANG Ying, RUAN Xiangyan, TIAN Xuanxuan, ZHANG Junli, Alfred O. Mueck. Development of progesterone receptor membrane component 1(PGRMC1) on the risk of breast cancer[J]. Journal of Capital Medical University, 2013, 34(4): 496-500.

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URL: https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/10.3969/j.issn.1006-7795.2013.04.004

https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/Y2013/V34/I4/496

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