Expression of tumor necrosis factor-α-inducible protein-2 in a mouse model of allergic rhinitis and its relationship with angiogenesis

doi:10.3969/j.issn.1006-7795.2013.06.002

Abstract

Abstract:

Objective To investigate the expression of tumor necrosis factor-α-inducible protein-2(TNFAIP2) in allergic rhinitis and its relationship with angiogenesis. Methods Allergic rhinitis mouse model was induced by ovalbumin(OVA), expression of TNFAIP2 and CD31(the marker of endothelial cells) in nasal mucosa was measured and correlation analysis was done. Results The number of nasal rubbing, serum OVA-specific IgE levels, and nasal mucosal eosinophil and mast cell infiltration were significantly higher in allergic rhinitis mouse model than in the control mice. Compared to the control mice, expression of TNFAIP2 mRNA and protein and CD31 mRNA in allergic rhinitis mouse model increased significantly. TNFAIP2 expression positively correlated with CD31. Conclusion TNFAIP2 may be involved in the development of allergic rhinitis via regulating the angiogenesis.

Key words: tumor necrosis factor-α-inducible protein-2, angiogenesis, allergic rhinitis

CLC Number:

R392.8

WANG Min, YANG Jun, SHANG Jun, ZHANG Luo. Expression of tumor necrosis factor-α-inducible protein-2 in a mouse model of allergic rhinitis and its relationship with angiogenesis[J]. Journal of Capital Medical University, 2013, 34(6): 790-794.

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URL: https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/10.3969/j.issn.1006-7795.2013.06.002

https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/Y2013/V34/I6/790

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