Journal of Capital Medical University ›› 2012, Vol. 33 ›› Issue (3): 399-402.doi: 10.3969/j.issn.1006-7795.2012.03.024

• 临床研究 • Previous Articles     Next Articles

Valsartan capsules, irbesartan tablets in the treatment of patients with diabetic nephropathy, clinical observation of 106 cases

Abudoushalamu·Abudoureyimu, LIU Tao1,2, Mierban·Abulike2, Muhuyati3   

  1. 1. Graduate Student of 6th Term, Graduate College, Xinjiang Medical University,Urumqi 830000, China;2. Department of Geriatrics, Traditional Chinese Medicine Hospital Affiliated to Xinjiang Medical University,Urumqi 830000, China;3. Institute of Pediatrics, Xinjiang Uygur Autonomous Region People's Hospital, Urumqi 830000, China;4. Department of General Cardiology, First Affiliated Hospital, Xinjiang Medical University, Urumqi 830054, China
  • Received:2012-03-25 Revised:1900-01-01 Online:2012-06-21 Published:2012-06-21

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Abstract: Objective This was a prospective observational study on effects of valsartan and irbesartan in patients with diabetic nephropathy on trace urinary albumin and blood pressure.Methods A prospective observational study was conducted on 106 cases of type 2 diabetic patients with nephropathy. The patients were randomly divided into two groups (A and B), patients in group A (n = 51) were treated with valsartan 80 mg/d, those in group B (n = 55) were treated with irbesartan 150 mg/d, for 12 weeks as a course, for each course of treatment, microalbuminuria, and blood pressure were measured for a total of three courses. Results (1) Valsartan and irbesartan groups' trace urinary albumin during three courses of treatment difference had statistically significant difference (Z=-6.490 P <0.001). (2) The blood pressure of the two groups during the three courses of treatment was significantly different (P <0.05); in each course of treatment the systolic blood pressure was significantly different (P<0.05).Conclusion Both drugs could reduce microalbuminuria and had antihypertensive effect in patients with diabetic nephropathy, while irbesartan was more effective in lowering blood pressure as compared with valsartan.

Key words: valsartan capsules, irbesartan tablets, diabetic nephropathy, urinary albumin, blood pressure

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