Effect of periodontal status on blood glucose control in patients with diabetic nephropathy

doi:10.3969/j.issn.1006-7795.2021.02.024

Abstract

Abstract: Objective This study explores the association between periodontal status and glycosylated hemoglobin (HbA1c)in patients with diabetic nephropathy (DN).Methods An observational study was conducted in 119 patients with DN. Patients were divided into two groups according to the presence of HbA1c<7% group (n=27) and HbA1c≥7% group (n=92), and oral health behavior-related variables were obtained by questionnaire. All patients underwent clinical examination, including probing depth(PD), bleeding index, clinical attachment loss(CAL) and the number of remaining teeth in the mouth. Laboratory tests include fasting blood glucose, glycosylated hemoglobin, creatinine and urine protein, etc. Results Comparied with HbA1c<7% group patients, probing depth (3.99±1.05 vs 3.49±0.93, P=0.031), blood index (3.45±0.58 vs 3.10±0.67, P=0.001), CAL (6.40±2.18 vs 5.37±1.99, P=0.003),the percentage of PD≥4 mm (median: 54.17% vs 38.15%, P=0.001) and PD≥5 mm (median: 24.13% vs 12.85%, P=0.028) were increased in HbA1c≥7% group patients. The results of multivariate Logistic regression analysis showed that in addition to fasting blood glucose, increasing of CAL was highly correlated with HbA1c ≥7% (OR=1.36, 95% CI:1.01-1.83,P=0.043) in DN patients. Conclusion There was a relationship between periodontal disease and HbA1c in patients with DN, increased CAL is highly correlated with poor HbA1c control in patients with diabetic nephropathy in DN.

Key words: diabetic nephropathy, HbA1c, periodontitis, clinical attachment loss

CLC Number:

R781.4

Zhang Dongxue, Lin Mei, Zhou Xuan, Liu Wenyan, Gu Yanan, Wang Zuomin. Effect of periodontal status on blood glucose control in patients with diabetic nephropathy[J]. Journal of Capital Medical University, 2021, 42(2): 306-311.

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https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/Y2021/V42/I2/306

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