Abstract: Objective To develop and evaluate early signs Inventory of relapse/worsen in schizophrenia(ESIS).Methods The primary version of ESISedited by interviewing family members of schizophrenics and summarizing literatures,and 200 patients' family members were measured formally and developed the formal inventory referring to the results of exploratory factor analysis.50 stable and 50 relapse/worsen patients were investigated to evaluate the validity and reliability of the inventory.Results Exploratory factor analysis reveals that drawing-out 6 factors were termed and formed a 28-question inventory,which could explain 52.306% of total variation.The correlations between item and total scale were 0.150～0.603(P<0.05).The correlations between item and subscale were 0.483～0.811(P<0.01).The score differences between stable and relapse/worsen patients except subscale 1,the total scale and another 5 subscales were significant(P<0.01).The total Cronbach α was 0.845 and the Cronbach α of each subscale was 0.590～0.779.The split-half reliability of ESISwas 0.719,while the split-half reliabilities of subscales was 0.501～0.772.The test-retest correlation of the whole scale was 0.721 and subscales' test-retest correlation coefficients were 0.484～0.900(P<0.01).Conclusion The reliability and validity of ESIS could reach the acceptable level in psychometrics,and this inventory may be used to instruct family members to identify early signs of relapse/worsen of patients.

Key words: schizophrenia, relapse, worsen, early signs, evaluation