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Effect of tongfu granules on intestinal microflora barrier function in rats with antibiotic-associated colitis LI Dan;REN Ai-min;WANG Hong;XU Shu-zhen Journal of Capital Medical University    2012, 33 (3): 315-321.   DOI: 10.3969/j.issn.1006-7795.2012.03.007 Abstract （1067）      PDF（pc） （2698KB）（5925）       Knowledge map    Save Objective To investigate the effects of Tongfu granules on intestinal microflora barrier function in rats with antibiotic-associated colitis. Tongfu granules which is a kind of Chinese traditional medicine. The present study aimed to investigate protecting effect of the medicine on impaired intestinal mucosa, and further study effects of Dahuang and Houpo which are the two main components of Tongfu granules. Methods Eighty male rats were divided into ten groups. After making the models of Lincomycin induced antibiotic-associated colitis, blood samples of rats were taken for measuring endotoxin.The colonic contents of rats were collected to culture four floras: bacillus acidi lactici, bacillus bifidus, enterococci bacillus coli. The pathological change of intestinal mucosa was observed using light microscope. Results The body weight of the model group was significantly decreased, a significant difference was shown between Houpo and Tongfu granule in weight. The endotoxin in rats of treatment group was decreased. But insignificant difference was shown among Dahuang, Houpo and Tongfu granule groups in endotoxin. There was a significant difference (P<0.05) between Tongfu granule and model group after treatment. The number of bacillus acidi lactici, bacillus bifidus, enterococci bacillus coli increased. The scores of the lesions showed a significant difference between Tongfu granule and Dahuang. Conclusion There was injury in intestinal mucosal barrier in antibiotic-associated colitis rats. Chinese Traditional medicine Tongfu granules Dahuang and Houpo had protective effects on the smalI intestinal barrier. They can decrease the endotoxin level of antibiotic-associated colitis rats. They also could recover the intestinal flora. Tongfu granule was better than Dahuang and Houpo. Related Articles | Metrics Cited: Baidu(3)

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Brief report on stroke prevention and treatment in China,2024 Stroke Prevention Project, National Health Commission, Ji Xunming Journal of Capital Medical University    2025, 46 (6): 947-960.   DOI: 10.3969/j.issn.1006-7795.2025.06.001 Abstract （2076）      PDF（pc） （5215KB）（1133）       Knowledge map    Save lthough China has a slight decline in stroke incidence in recent years, it still seems to be the leading health threat to Chinese citizens. China continues to bear a heavy stroke burden which has distinct epidemiological characteristics, while major risk factors remain prevalent and poorly controlled. Markedly, the government is putting effort into advancing the stroke prevention and treatment system, meanwhile, continuously funding cerebrovascular disease research, and driving steady improvements in diagnosis and treatment capabilities. However,  stroke prevention and control work in China still faces considerable challenges. This report systematically reviews the current state of stroke prevention and treatment in China during 2023 from five perspectives: epidemiological characteristics, risk factors, diagnostic and therapeutic advances, prevention system development and stroke center construction, aiming to provide references for clinical practice. Reference | Related Articles | Metrics

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Application research hotspot of traditional Chinese medicine informatics Gao Man, Li Haiyan Journal of Capital Medical University    2022, 43 (4): 592-599.   DOI: 10.3969/j.issn.1006-7795.2022.04.013 Abstract （390）      PDF（pc） （1014KB）（1323）       Knowledge map    Save This paper summarized the popular applications of traditional Chinese medicine(TCM) informatics research to provide useful references for researchers, which include TCM clinical data mining and utilization, TCM intelligent diagnosis and treatment equipment research, Chinese medicine information research, discipline knowledge service based on TCM ancient and modern literature information, and TCM evaluation research based on big data. Reference | Related Articles | Metrics

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Transport System in Cells——Introduction of Nobel Prize in Physiology or Medicine 2013 ZHANG Ting, WANG Xiaomin Journal of Capital Medical University    2013, 34 (5): 776-781.   DOI: 10.3969/j.issn.1006-7795.2013.05.029 Abstract （1129）      PDF（pc） （1918KB）（1483）       Knowledge map    Save The Nobel Prize in Physiology or Medicine 2013 is divided to James E. Rothman, Randy W. Schekman and Thomas C. Südhof, for their discoveries of machinery regulating vesicle traffic, a major transport system in our cells. Reference | Related Articles | Metrics

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Progress on the injury and repair mechanism of renal tubular epithelial cells in the transition of acute kidney injury to chronic kidney disease Chen Xiaomei, Ma Yuanyuan, Nie Jing, Zhu Fengxin Journal of Capital Medical University    2022, 43 (5): 720-727.   DOI: 10.3969/j.issn.1006-7795.2022.05.009 Abstract （511）      PDF（pc） （1051KB）（706）       Knowledge map    Save Acute kidney injury (AKI) is a clinical syndrome caused by various factors and characterized by renal function declines sharply in a short period of time. AKI, an independent risk factor of chronic kidney disease (CKD) and end-stage renal disease, is associated with high levels of morbidity and mortality. Currently, the treatments for AKI and the prevention of the transition of AKI to CKD are very limited. Therefore, it is essential to explore the mechanism of AKI to CKD. Renal tubular epithelial cells (RTECs) are the major cells of the kidney and are vulnerable to various biological stresses, such as ischemia, hypoxia and toxins.RTECs are also key inflammatory and fibrogenic cells that drive the progression from acute to chronic kidney disease. In view of the central role of RTECs, this review will focus on the maladaptive repair mechanisms of RTECs in the transition of AKI to CKD, providing novel targets and new strategies for effective treatment. Reference | Related Articles | Metrics

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Effect of Bilateral Vagotomy on the Arrythmias and Pressor Response Induced by Stimulation of the Hypothamus in Rabbits Qu Ruiyao;Yang Guojie Journal of Capital Medical University    1988, 9 (3): 182-188.   Abstract （674）      PDF（pc） （2674KB）（836）       Knowledge map    Save In rabbits under local anesthesia and immobilization extrasystales and elevation of arteral blood pressure could be provoked by stimulation of the Lateral Hypothalamic Area (LHA) and Ventromedial Hypothalamic Nucleus (VMH) with 15～70μA, 70Hz and 1ms duration square wave current. They have relatively differential. Brady-arrythmias, bradycardias, sinus cadiac arrest and block, could be provoked and its produce rade was higher during stimulation of LHA; on the other hand, tacky-arrythmias, frequent Hypothalamic stimulation-induced Ventricular Extrasystale (HVE) and tackycardias could be provoked and its produce rate Was higher during stimulation of VMH. Stimlus-eveked brady-arrythmia of LHA or VMH could be deleted or damped by injection Atropine of bilateral vagotomy, but stimulus-evoked tacky-arrhythmai of VMH could be deleted of damped. Stimulus-evoked tacky-arrythmia of VMH of LHA could be abated or damped by injection of Phentolamin and/or Propranolol, but stimulus-evoked brady-arrythmia of LHA could even more be enhanced of facilitied. Related Articles | Metrics

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Prevalence of female sexual dysfunction and the relationship between climacteric symptoms and female sexual dysfunction in Chinese women with menopause transition stage and postmenopausal stage Ju Rui, Ruan Xiangyan, Xu Xin, Yang Yu, Zhang Luping, Qin Shuang, Wang Binhong, Dou Zhuli, Alfred O. Mueck Journal of Capital Medical University    2020, 41 (4): 503-507.   DOI: 10.3969/j.issn.1006-7795.2020.04.001 Abstract （346）      PDF（pc） （1184KB）（723）       Knowledge map    Save Objective To investigate the effects of climacteric symptoms on female sexual dysfunction(FSD) at different reproductive aging stages. Methods A cross-sectional study including 180 cases was conducted among women over 40 years old in the Department of Gynecological Endocrinology, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing, China, from Jun. 2019 to Oct. 2019. According to the 2011 stages of the Reproductive Ageing Workshop (STRAW+10), the subjects were divided into four groups:early menopausal transition stage (group A), late menopausal transition stage (group B), early postmenopausal stage (group C), and late postmenopausal stage (group D). Female climacteric symptoms were evaluated by Modified Kupperman Index (KMI), and FSD was evaluated by Female Sexual Function Index (FSFI). Results With the increase of stages of the reproductive aging, the median age of the subjects increased from 45.5 years to 57.0 years, the median years of cohabitation with their partners increased from 20 years to 23.5 years, the median time of sexual frequency increased from 7 days to 15 days, and the median KMI increased from 9.5 to 15 days (P<0.05). With the increase of stages of the reproductive aging, the prevalence of FSD and sexual desire disorder, sexual arousal disorder, vaginal lubrication disorder, orgasm disorder, sexual satisfaction disorder, and vaginal pain were significantly increased (P<0.05). The prevalence of FSD and sexual desire disorder, sexual arousal disorder, vaginal lubrication disorder, orgasm disorder, sexual satisfaction disorder, and vaginal pain increased with the severity of menopausal symptoms (P<0.05). Conclusion With advanced stage of reproductive aging, FSD was prevalent significantly. The prevalence of FSD was higher in women with menopausal symptoms. The more severe the menopausal symptoms were, the higher the prevalence of FSD was. Climacteric symptoms and their severity are important factors affecting the occurrence of FSD in women over 40 years old. Climacteric symptoms should be actively treated to improve the quality of life of women. Reference | Related Articles | Metrics

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Evaluation of Middle Cerebral Artery Occlusion Induced Focal Cerebral Ischemia Model in Mice YU Pei-lan, SUI Lei-ming, HAN Song, ZHAO Huan-ying, JIANG Jun, LI Jun-fa Journal of Capital Medical University    2010, 31 (5): 586-590.   DOI: 10.3969/j.issn.1006-7795.2010.05.014 Abstract （1669）      PDF（pc） （362KB）（1515）       Knowledge map    Save Objective To study the success rate and reliability of middle cerebral artery occlusion(MCAO) model by objective and reliable neurological score, infarct volume, and edema rate. Methods Cerebral ischemia model of MCAO was established in mouse using the suture method. Infarct volume, edema rate and behavioral performance was evaluated by 2,3,5-triphenyltetrazolium chloride(TTC) staining and neurological score. Results MCAO could induce obvious focal cerebral ischemia by TTC staining and the success rate of this model was about 90.8%. Besides, MCAO could induce three types of cerebral ischemia: cortical, hippocampal and thalamic ischemia. And the predominant type is cortical ischemia. MCAO-induced cerebral ischemia could significantly increase the neurological score compared with the sham group. The procedure for infarct volume evaluation of the MCAO model was accurate and stable; infarct volume was about 35% of entire brain volume. Conclusion Cerebral ischemia model of MCAO was established in mice successfully(90.8%). The evaluation of neurological deficit and infarct volume was technically reliable. Related Articles | Metrics Cited: Baidu(7)

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Association between thyroid-stimulating hormone and serum lipid in patients with polycystic ovary syndrome Yin Dongmei, Ruan Xiangyan, Lu Yongjun, Wu Hongqin, Tian Xuanxuan, Diethelm Wallwiener, Alfred O. Mueck Journal of Capital Medical University    2014, 35 (4): 424-427.   DOI: 10.3969/j.issn.1006-7795.2014.04.008 Abstract （714）      PDF（pc） （1015KB）（888）       Knowledge map    Save Objective To investigate the differences in clinical features, endocrine metabolic parameters of polycystic ovary syndrome patients with different levels of serum thyroid-stimulating hormone. Methods One hundred and ten PCOS patients were enrolled. Height, weight, waist circumference, hip circumferences were measured. Chemiluminescence was applied for measuring thyroid-stimulating hormone(TSH), total cholesterol(TC), low density lipoprotein(LDL), high density lipoprotein(HDL), triglyceride(TG), fasting blood-glucose(FBG), fasting insulin(INS), follicle-stimulating hormone(FSH), luteinizing hormone(LH), testosterone(T), prolactin(PRL) and estradiol(E2); Body mass index(BMI), waist-to-hip circumference ratio(WHR), LH-to-FSH ratio(LH/FSH) were calculated; The insulin resistance index evaluated by steady-state model(HOMA-IR); all patients were divided into two groups according to serum thyroid-stimulating hormone: group A had 71 cases with TSH<2.5 mIu/L, as group B of 39 cases with TSH≥2.5 mIu/L; all the hormone parameters mentioned above were compared between group A and B, and the correlation with TSH. Results The WHR and LDL in group B(TSH≥2.5 mIu/L) is significantly higher than that of the patients in group A(TSH<2.5 mIu/L). The increase of TSH concentration positively correlates to an increase of WHR, TC, LDL-C and PRL. No significant differences are shown in other clinical and metabolic indicators. Conclusion There was a significant correlation between TSH and lipid metabolic parameters. Women with polycystic ovary syndrome and with thyroid-stimulating hormone≥2.5 mIu/L had significantly endocrine and metabolic changes. Reference | Related Articles | Metrics Cited: Baidu(3)

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Journal of Capital Medical University    1997, 18 (2): 197-200.   Abstract （485）      PDF（pc） （505KB）（796）       Knowledge map    Save Related Articles | Metrics

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Application of artificial intelligence in the study of cancer diagnosis and treatment research Liu Honglei, Yang Yingliang, Li Ronghao, Zhu Congmin, Zhang Xu Journal of Capital Medical University    2025, 46 (3): 395-400.   DOI: 10.3969/j.issn.1006-7795.2025.03.001 Abstract （233）      PDF（pc） （460KB）（294）       Knowledge map    Save As a major global public health concern, cancer has witnessed a continues  rise in both incidence and mortality rates. It pose not only a severe threat to human health but also a heavy burden on socioeconomic systems. Despite remarkable advancements in oncology research, critical challenges such as tumor heterogeneity, drug resistance, and limitations in early screening and diagnostic technologies remain to be addressed. Against this backdrop, artificial intelligence (AI), with its unique advantages in big data analysis, pattern recognition, and predictive modeling, has opened new avenues for cancer research. By integrating multi-modal data, including omics, imaging, and clinical information, AI not only accelerates investigations into fundamental tumor mechanisms but also demonstrates immense potential in areas such as early screening, biomarker discovery, and personalized treatment. These advancements have fostered a deeper integration of precision medicine and oncology. This review provides a comprehensive overview of the most recent progresses in the application of AI in cancer diagnosis and treatment research, with a focus on its practical value across diverse data types and clinical scenarios, as well as future directions for its development. Reference | Related Articles | Metrics

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Journal of Capital Medical University    2022, 43 (5): 813-816.   DOI: 10.3969/j.issn.1006-7795.2022.05.024 Abstract （196）      PDF（pc） （3147KB）（682）       Knowledge map    Save Reference | Related Articles | Metrics

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A systematic approach to constructing DAG from knowledge graph Bai Yongmei, Sun Huage, Du Jian Journal of Capital Medical University    2022, 43 (4): 584-591.   DOI: 10.3969/j.issn.1006-7795.2022.04.012 Abstract （763）      PDF（pc） （4994KB）（501）       Knowledge map    Save Causal inference is the primary goal of observational research based on big data, as opposed to correlation analysis. Causal graph often visualize complex causal relationships by integrating large amount of priori knowledge through directed acyclic graph(DAG). The directed acyclic graph has become an important tool for developing causal inference strategies. However, the construction of causal graph for specific research questions currently relies heavily on expert knowledge and local experience. Medical knowledge extraction from existing publications is the basis for the systematic construction of DAG. In this paper, we will systematically introduce the structured medical knowledge system platform developed based on the SemMedDB database of the National Institutes of Health. This study attempts to provide a new strategy for systematically constructing DAG by defining causal graphs from an interdisciplinary perspective as complex networks between the concepts involved in a research problem (head and tail concepts) and all their third-party variables. There are two main approaches for the current systematic construction of causal graphs: (1) Prune the knowledge graph into causal graph; (2) Combine the evidence claims based on population-interventions/exposure-comparisons-outcomes (PI/ECO) framework into causal graphs. Reference | Related Articles | Metrics

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The relationship between psychogenic erectile dysfunction of kidney deficiency type and attention network dysfunction Dong Linrui, Yan Bin, Feng Sitong, Ning Yanzhe, Feng Zhengtian, Jia Hongxiao Journal of Capital Medical University    2022, 43 (3): 393-397.   DOI: 10.3969/j.issn.1006-7795.2022.03.011 Abstract （273）      PDF（pc） （1050KB）（325）       Knowledge map    Save Objective To investigate the relationship between psychogenic erectile dysfunction (pED) of kidney deficiency type (KD) and attention network dysfunction. Methods A total of 26 patients with pED of KD type and 24 were recruited from Xiyuan Hospital of China Academy of Chinese Medical Science from March 2021 to January 2022. And 24 healthy males were recruited as the control group according to the principle of matching between groups in terms of age, sex and years of education.Both study groups underwent attention network test (ANT). Results Compared with healthy subjects, the patients with pED of KD type showed significantly poorer efficiency on executive control network and overall mean reaction time (P<0.05). The alerting network efficiency, orienting network efficiency and mean correctness rates were not statistically significant compared to normal control subjects (P>0.05). Furthermore, efficiency on executive control network was positively associated with the scores of kidney yang deficiency(r=0.408,P=0.039).And the multi-factor Logistic regression analysis showed efficiency on executive control network was positively associated with pED of KD type (P<0.05). Conclusion Our findings suggested that patients with pED of KD type exhibited impairments of executive control network, which may be related to altered neural activities in brain regions associated with executive control functions. It provided a modern scientific basis for the treatment of psychogenic erectile dysfunction of kidney deficiency type by Chinese medicine theory of kidney. Reference | Related Articles | Metrics

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Clinical analysis and experience summary of large vulvar ulcers in women Gao Guangcheng, Sun Xin, Xu Ying, Zhuo Fenglin Journal of Capital Medical University    2021, 42 (6): 1046-1052.   DOI: 10.3969/j.issn.1006-7795.2021.06.023 Abstract （396）      PDF（pc） （16645KB）（272）       Knowledge map    Save Objective To explore the clinical manifestations and differential diagnosis of large vulvar ulcers. Methods By analyzing the clinical data of 3 patients with large vulvar ulcer and literature reports, the types and clinical manifestations of large vulvar ulcers were listed for diagnosis and differential diagnosis. Results Three cases of large vulvar ulcer were diagnosed as Behcet’s disease, fixed drug rash and acute vulvar ulcer, respectively, based on clinical manifestations and laboratory examinations. They were cured after treatments. Conclusion Acute vulvar ulcer, Behcet’s syndrome, fixed drug rash, extramammary Paget’s disease, chemical burn and radiation ulcer should be considered in the cases of large vulvar ulcers. Especially the diagnosis and differential diagnosis of Behcet’s disease and acute vulvar ulcer are more critical. Behcet’s disease can be diagnosed when patients have oral ulcer and vulvar ulcer. Reference | Related Articles | Metrics

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Clinical Experience on Local Nerve Blockade Anaesthesia for Tension-free Inguinal Hernia Repairing in the Senile Patients Wang Minggang;Chen Jie;Liu Sujun;Shen Yingmo;Bao Shaoyu;Zhu Dawei Journal of Capital Medical University    2008, 29 (6): 770-772.   Abstract （805）      PDF（pc） （168KB）（764）       Knowledge map    Save Objective To evaluate the curative effect of local nerve blockade anaesthesia for tension-free inguinal hernia repairing in senile patients.Methods 3257 senile patients with tension-free hernioplasty under local nerve blockade anaesthesia from Feb2002 to Jun2008 in our center were analyzed.Results The operative time was 18 to 50 minutes at average time 28 minutes.All patients had good anaesthetic condition and no urinary retention,except one case with infective wound,36 cases with scrotal hydrocles and 5 cases with chronic pain.The average stay in hospital was 2.9 days,and the average cost was 4267 yuan(RMB).4 cases had recurrence and no one had the feeling of foreign body follow-up in an average of 48 months.Conclusion The open groin tension-free hernioplasty under local nerve blockade anaesthesia is a safe and credible operation procedure. Related Articles | Metrics Cited: Baidu(3)

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Characteristics and governance of retracted papers from “paper mills” Zhang Jianjun, Zhuang Ying, Sun Chaoyuan, Gao Jian, Yan Hong, Jin Haizheng Journal of Capital Medical University    2026, 47 (1): 202-211.   DOI: 10.3969/j.issn.1006-7795.2026.01.026 Abstract （38）      PDF（pc） （639KB）（220）       Knowledge map    Save Objective  To systematically analyze the characteristics of articles retracted due to “paper mills” and explore effective governance strategies to uphold academic integrity. Methods  Based on data from the Retraction Watch Database (2010-2024), a total of 7 513 articles retracted due to “paper mills” were included. Descriptive statistics and categorical analysis were employed to examine disciplinary distribution, national characteristics, article types, retraction timelines, publisher sources, and retraction reasons. Results  Retracted articles were primarily concentrated in Business & Technology (48.3%) and Basic Life Sciences (38.1%). China (including Taiwan Province) contributed to 88.5% of global retractions. Research articles constituted the majority of retracted types (88.3%). The average retraction period was 761.5 d. Publishers such as Hindawi and IOP Publishing were major sources of retractions. Key contributing factors included third-party investigations, data irregularities, and peer review fraud. Conclusion  Retractions linked to “paper mills” exhibit features such as disciplinary concentration, geographical imbalance, publisher accountability deficits, and retraction delays. Multifaceted governance strategies—including reforming academic evaluation systems, strengthening journal review mechanisms, promoting international cooperation, and enhancing research ethics education—are essential to combat paper mill activities and safeguard the integrity of scientific research. Reference | Related Articles | Metrics

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The application of artificial intelligence in stomatology Xie Lizhe , Yan Bin , Wang Lin Journal of Capital Medical University    2025, 46 (6): 968-976.   DOI: 10.3969/j.issn.1006-7795.2025.06.003 Abstract （98）      PDF（pc） （3267KB）（219）       Knowledge map    Save With the rapid development of artificial intelligence (AI) technology, it has been deeply integrated into the entire workflow of stomatological diagnosis and treatment, and it is widely applied in key aspects such as prevention, diagnosis, treatment, risk assessment, and prognosis evaluation. Herein we systematically reviews the research progress and application status of AI technology in stomatological diagnosis and treatment, focuses on the implementation effects of core technologies in typical clinical scenarios of stomatology, conducts an in-depth analysis of the major bottlenecks and challenges encountered in current practice, and puts forward a forward-looking prospect for its future development. It aims to provide a theoretical basis and practical reference for the construction and optimization of the intelligent diagnosis and treatment system in stomatology. Reference | Related Articles | Metrics

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Research progress of psoriasis-like models DI Ting-ting;ZHAO Jing-xia;LI Ping Journal of Capital Medical University    2012, 33 (2): 275-279.   DOI: 10.3969/j.issn.1006-7795.2012.02.030 Abstract （1137）      PDF（pc） （1015KB）（2179）       Knowledge map    Save Lack of the naturally occurred psoriasis animal models once made the researches on human psoriasis phenotype and pathogenesis stagnated in last several years. But with the increasing understanding of psoriasis mechanism, a series of models has been explored at organic, cellular and molecular levels. We evaluated the current psoriasis models and analyze theirs advantages and limitations, to provide reference for psoriasis studying, drug screening and treatment. Related Articles | Metrics Cited: Baidu(2)

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Aortic arch reconstruction for acute type A aortic dissection Sun Lizhong, Rong Tianhua Journal of Capital Medical University    2015, 36 (3): 338-344.   DOI: 10.3969/j.issn.1006-7795.2015.03.002 Abstract （420）      PDF（pc） （1095KB）（453）       Knowledge map    Save Acute type A aortic dissection involving the aortic arch remains an inherently lethal medical condition ever since it is known to us. Prompt diagnosis and proper treatment is urgently needed and supposed to significantly lower the mortality rate. Although open surgical repair is undoubtedly the mainstream technique now, high rate of postoperative mortality and morbidity has always been a formidable challenge. Along with the rapid development of the aortic surgery and cognition of the disease, a variety of approaches have been invented or introduced, mostly aiming at simplifying procedure, minimizing surgical trauma and improving prognoses at the same time. Apart from the conventional surgical operation, recently emerged Sun's procedure, open branched stent graft placement, hybrid procedure, and even the endovascular repair have been taken into consideration. However, the more choices we have, the more we come to realize that ideal techniques with the characteristics of stability, convenience, riskless, effectiveness and wide applicability remain to be pursued. Because of the complexity of aortic arch in aspects of anatomy, function and pathological changes, the appropriate approach for patients with type A dissection involving the aortic arch remains controversial. This article provides current information about strategies of aortic arch reconstruction used for acute type A aortic dissection by reviewing related publications as well as brief discussions. Reference | Related Articles | Metrics