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Effect of tongfu granules on intestinal microflora barrier function in rats with antibiotic-associated colitis LI Dan;REN Ai-min;WANG Hong;XU Shu-zhen Journal of Capital Medical University    2012, 33 (3): 315-321.   DOI: 10.3969/j.issn.1006-7795.2012.03.007 Abstract （1046）      PDF（pc） （2698KB）（5897）       Knowledge map    Save Objective To investigate the effects of Tongfu granules on intestinal microflora barrier function in rats with antibiotic-associated colitis. Tongfu granules which is a kind of Chinese traditional medicine. The present study aimed to investigate protecting effect of the medicine on impaired intestinal mucosa, and further study effects of Dahuang and Houpo which are the two main components of Tongfu granules. Methods Eighty male rats were divided into ten groups. After making the models of Lincomycin induced antibiotic-associated colitis, blood samples of rats were taken for measuring endotoxin.The colonic contents of rats were collected to culture four floras: bacillus acidi lactici, bacillus bifidus, enterococci bacillus coli. The pathological change of intestinal mucosa was observed using light microscope. Results The body weight of the model group was significantly decreased, a significant difference was shown between Houpo and Tongfu granule in weight. The endotoxin in rats of treatment group was decreased. But insignificant difference was shown among Dahuang, Houpo and Tongfu granule groups in endotoxin. There was a significant difference (P<0.05) between Tongfu granule and model group after treatment. The number of bacillus acidi lactici, bacillus bifidus, enterococci bacillus coli increased. The scores of the lesions showed a significant difference between Tongfu granule and Dahuang. Conclusion There was injury in intestinal mucosal barrier in antibiotic-associated colitis rats. Chinese Traditional medicine Tongfu granules Dahuang and Houpo had protective effects on the smalI intestinal barrier. They can decrease the endotoxin level of antibiotic-associated colitis rats. They also could recover the intestinal flora. Tongfu granule was better than Dahuang and Houpo. Related Articles | Metrics Cited: Baidu(3)

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Clinical Characteristics of Aspirin Resistance in Patients with Cardiovascular Diseases Zhu Zhengyan;Hu Dayi;Shi Xubo;Wang Chunbo;Zhu Jingyan;Yang Jingang;Li Tianchang Journal of Capital Medical University    2005, 26 (2): 128-131.   Abstract （895）      PDF（pc） （403KB）（2276）       Knowledge map    Save Objective The study was designed to investigate the clinical characteristics of aspirin resistance in patients with cardiovascular diseases.Methods 326 patients with stable cardiovascular diseases were evaluated for aspirin resistance with idetection of optical platelet aggregation induced by arachidonic acid(AA) and adenosine diphosphate(ADP). Aspirin resistance was defined as an average aggregation of over 20% with 0.5 mmol/L AAand over 70% with 10 μmol/L ADP. Aspirin semiresistance met one, but not both of the above criteria. Results 4.9% of the patients were aspirin resistant and 27.6% were aspirin-semiresistant. The clinical characteristics of aspirin resistant patients compared with aspirin sensitive patients were: 1) most of the aspirin-resistant patients were senile; 2) female patients were more frequent than male; 3) patients with diabetes were dominant in number; 4) it had nothing to do with hypertension, hyperlipodemia, red blood cell count, hemoglobin and platelet count; 5) it was relatively rare in smoking population. Conclusion The incidence of aspirin resistance is similar to other studies, in addition to aging and female gender, diabetes is also a risk factor in aspirin resistance. Related Articles | Metrics

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Application research hotspot of traditional Chinese medicine informatics Gao Man, Li Haiyan Journal of Capital Medical University    2022, 43 (4): 592-599.   DOI: 10.3969/j.issn.1006-7795.2022.04.013 Abstract （361）      PDF（pc） （1014KB）（1316）       Knowledge map    Save This paper summarized the popular applications of traditional Chinese medicine(TCM) informatics research to provide useful references for researchers, which include TCM clinical data mining and utilization, TCM intelligent diagnosis and treatment equipment research, Chinese medicine information research, discipline knowledge service based on TCM ancient and modern literature information, and TCM evaluation research based on big data. Reference | Related Articles | Metrics

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Transport System in Cells——Introduction of Nobel Prize in Physiology or Medicine 2013 ZHANG Ting, WANG Xiaomin Journal of Capital Medical University    2013, 34 (5): 776-781.   DOI: 10.3969/j.issn.1006-7795.2013.05.029 Abstract （1073）      PDF（pc） （1918KB）（1455）       Knowledge map    Save The Nobel Prize in Physiology or Medicine 2013 is divided to James E. Rothman, Randy W. Schekman and Thomas C. Südhof, for their discoveries of machinery regulating vesicle traffic, a major transport system in our cells. Reference | Related Articles | Metrics

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Effect of Bilateral Vagotomy on the Arrythmias and Pressor Response Induced by Stimulation of the Hypothamus in Rabbits Qu Ruiyao;Yang Guojie Journal of Capital Medical University    1988, 9 (3): 182-188.   Abstract （662）      PDF（pc） （2674KB）（828）       Knowledge map    Save In rabbits under local anesthesia and immobilization extrasystales and elevation of arteral blood pressure could be provoked by stimulation of the Lateral Hypothalamic Area (LHA) and Ventromedial Hypothalamic Nucleus (VMH) with 15～70μA, 70Hz and 1ms duration square wave current. They have relatively differential. Brady-arrythmias, bradycardias, sinus cadiac arrest and block, could be provoked and its produce rade was higher during stimulation of LHA; on the other hand, tacky-arrythmias, frequent Hypothalamic stimulation-induced Ventricular Extrasystale (HVE) and tackycardias could be provoked and its produce rate Was higher during stimulation of VMH. Stimlus-eveked brady-arrythmia of LHA or VMH could be deleted or damped by injection Atropine of bilateral vagotomy, but stimulus-evoked tacky-arrhythmai of VMH could be deleted of damped. Stimulus-evoked tacky-arrythmia of VMH of LHA could be abated or damped by injection of Phentolamin and/or Propranolol, but stimulus-evoked brady-arrythmia of LHA could even more be enhanced of facilitied. Related Articles | Metrics

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Journal of Capital Medical University    1997, 18 (2): 197-200.   Abstract （485）      PDF（pc） （505KB）（779）       Knowledge map    Save Related Articles | Metrics

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Evaluation of Middle Cerebral Artery Occlusion Induced Focal Cerebral Ischemia Model in Mice YU Pei-lan, SUI Lei-ming, HAN Song, ZHAO Huan-ying, JIANG Jun, LI Jun-fa Journal of Capital Medical University    2010, 31 (5): 586-590.   DOI: 10.3969/j.issn.1006-7795.2010.05.014 Abstract （1638）      PDF（pc） （362KB）（1488）       Knowledge map    Save Objective To study the success rate and reliability of middle cerebral artery occlusion(MCAO) model by objective and reliable neurological score, infarct volume, and edema rate. Methods Cerebral ischemia model of MCAO was established in mouse using the suture method. Infarct volume, edema rate and behavioral performance was evaluated by 2,3,5-triphenyltetrazolium chloride(TTC) staining and neurological score. Results MCAO could induce obvious focal cerebral ischemia by TTC staining and the success rate of this model was about 90.8%. Besides, MCAO could induce three types of cerebral ischemia: cortical, hippocampal and thalamic ischemia. And the predominant type is cortical ischemia. MCAO-induced cerebral ischemia could significantly increase the neurological score compared with the sham group. The procedure for infarct volume evaluation of the MCAO model was accurate and stable; infarct volume was about 35% of entire brain volume. Conclusion Cerebral ischemia model of MCAO was established in mice successfully(90.8%). The evaluation of neurological deficit and infarct volume was technically reliable. Related Articles | Metrics Cited: Baidu(7)

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Prevalence of female sexual dysfunction and the relationship between climacteric symptoms and female sexual dysfunction in Chinese women with menopause transition stage and postmenopausal stage Ju Rui, Ruan Xiangyan, Xu Xin, Yang Yu, Zhang Luping, Qin Shuang, Wang Binhong, Dou Zhuli, Alfred O. Mueck Journal of Capital Medical University    2020, 41 (4): 503-507.   DOI: 10.3969/j.issn.1006-7795.2020.04.001 Abstract （333）      PDF（pc） （1184KB）（700）       Knowledge map    Save Objective To investigate the effects of climacteric symptoms on female sexual dysfunction(FSD) at different reproductive aging stages. Methods A cross-sectional study including 180 cases was conducted among women over 40 years old in the Department of Gynecological Endocrinology, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing, China, from Jun. 2019 to Oct. 2019. According to the 2011 stages of the Reproductive Ageing Workshop (STRAW+10), the subjects were divided into four groups:early menopausal transition stage (group A), late menopausal transition stage (group B), early postmenopausal stage (group C), and late postmenopausal stage (group D). Female climacteric symptoms were evaluated by Modified Kupperman Index (KMI), and FSD was evaluated by Female Sexual Function Index (FSFI). Results With the increase of stages of the reproductive aging, the median age of the subjects increased from 45.5 years to 57.0 years, the median years of cohabitation with their partners increased from 20 years to 23.5 years, the median time of sexual frequency increased from 7 days to 15 days, and the median KMI increased from 9.5 to 15 days (P<0.05). With the increase of stages of the reproductive aging, the prevalence of FSD and sexual desire disorder, sexual arousal disorder, vaginal lubrication disorder, orgasm disorder, sexual satisfaction disorder, and vaginal pain were significantly increased (P<0.05). The prevalence of FSD and sexual desire disorder, sexual arousal disorder, vaginal lubrication disorder, orgasm disorder, sexual satisfaction disorder, and vaginal pain increased with the severity of menopausal symptoms (P<0.05). Conclusion With advanced stage of reproductive aging, FSD was prevalent significantly. The prevalence of FSD was higher in women with menopausal symptoms. The more severe the menopausal symptoms were, the higher the prevalence of FSD was. Climacteric symptoms and their severity are important factors affecting the occurrence of FSD in women over 40 years old. Climacteric symptoms should be actively treated to improve the quality of life of women. Reference | Related Articles | Metrics

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Association between thyroid-stimulating hormone and serum lipid in patients with polycystic ovary syndrome Yin Dongmei, Ruan Xiangyan, Lu Yongjun, Wu Hongqin, Tian Xuanxuan, Diethelm Wallwiener, Alfred O. Mueck Journal of Capital Medical University    2014, 35 (4): 424-427.   DOI: 10.3969/j.issn.1006-7795.2014.04.008 Abstract （695）      PDF（pc） （1015KB）（862）       Knowledge map    Save Objective To investigate the differences in clinical features, endocrine metabolic parameters of polycystic ovary syndrome patients with different levels of serum thyroid-stimulating hormone. Methods One hundred and ten PCOS patients were enrolled. Height, weight, waist circumference, hip circumferences were measured. Chemiluminescence was applied for measuring thyroid-stimulating hormone(TSH), total cholesterol(TC), low density lipoprotein(LDL), high density lipoprotein(HDL), triglyceride(TG), fasting blood-glucose(FBG), fasting insulin(INS), follicle-stimulating hormone(FSH), luteinizing hormone(LH), testosterone(T), prolactin(PRL) and estradiol(E2); Body mass index(BMI), waist-to-hip circumference ratio(WHR), LH-to-FSH ratio(LH/FSH) were calculated; The insulin resistance index evaluated by steady-state model(HOMA-IR); all patients were divided into two groups according to serum thyroid-stimulating hormone: group A had 71 cases with TSH<2.5 mIu/L, as group B of 39 cases with TSH≥2.5 mIu/L; all the hormone parameters mentioned above were compared between group A and B, and the correlation with TSH. Results The WHR and LDL in group B(TSH≥2.5 mIu/L) is significantly higher than that of the patients in group A(TSH<2.5 mIu/L). The increase of TSH concentration positively correlates to an increase of WHR, TC, LDL-C and PRL. No significant differences are shown in other clinical and metabolic indicators. Conclusion There was a significant correlation between TSH and lipid metabolic parameters. Women with polycystic ovary syndrome and with thyroid-stimulating hormone≥2.5 mIu/L had significantly endocrine and metabolic changes. Reference | Related Articles | Metrics Cited: Baidu(3)

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Journal of Capital Medical University    2022, 43 (5): 813-816.   DOI: 10.3969/j.issn.1006-7795.2022.05.024 Abstract （188）      PDF（pc） （3147KB）（640）       Knowledge map    Save Reference | Related Articles | Metrics

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Journal of Capital Medical University    2004, 25 (3): 411-414.   Abstract （815）      PDF（pc） （323KB）（1125）       Knowledge map    Save Related Articles | Metrics

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A systematic approach to constructing DAG from knowledge graph Bai Yongmei, Sun Huage, Du Jian Journal of Capital Medical University    2022, 43 (4): 584-591.   DOI: 10.3969/j.issn.1006-7795.2022.04.012 Abstract （736）      PDF（pc） （4994KB）（492）       Knowledge map    Save Causal inference is the primary goal of observational research based on big data, as opposed to correlation analysis. Causal graph often visualize complex causal relationships by integrating large amount of priori knowledge through directed acyclic graph(DAG). The directed acyclic graph has become an important tool for developing causal inference strategies. However, the construction of causal graph for specific research questions currently relies heavily on expert knowledge and local experience. Medical knowledge extraction from existing publications is the basis for the systematic construction of DAG. In this paper, we will systematically introduce the structured medical knowledge system platform developed based on the SemMedDB database of the National Institutes of Health. This study attempts to provide a new strategy for systematically constructing DAG by defining causal graphs from an interdisciplinary perspective as complex networks between the concepts involved in a research problem (head and tail concepts) and all their third-party variables. There are two main approaches for the current systematic construction of causal graphs: (1) Prune the knowledge graph into causal graph; (2) Combine the evidence claims based on population-interventions/exposure-comparisons-outcomes (PI/ECO) framework into causal graphs. Reference | Related Articles | Metrics

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Clinical Experience on Local Nerve Blockade Anaesthesia for Tension-free Inguinal Hernia Repairing in the Senile Patients Wang Minggang;Chen Jie;Liu Sujun;Shen Yingmo;Bao Shaoyu;Zhu Dawei Journal of Capital Medical University    2008, 29 (6): 770-772.   Abstract （801）      PDF（pc） （168KB）（753）       Knowledge map    Save Objective To evaluate the curative effect of local nerve blockade anaesthesia for tension-free inguinal hernia repairing in senile patients.Methods 3257 senile patients with tension-free hernioplasty under local nerve blockade anaesthesia from Feb2002 to Jun2008 in our center were analyzed.Results The operative time was 18 to 50 minutes at average time 28 minutes.All patients had good anaesthetic condition and no urinary retention,except one case with infective wound,36 cases with scrotal hydrocles and 5 cases with chronic pain.The average stay in hospital was 2.9 days,and the average cost was 4267 yuan(RMB).4 cases had recurrence and no one had the feeling of foreign body follow-up in an average of 48 months.Conclusion The open groin tension-free hernioplasty under local nerve blockade anaesthesia is a safe and credible operation procedure. Related Articles | Metrics Cited: Baidu(3)

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Hepatotoxicity Caused by Commonly-used Chinese Medicinal Herbs and Compound Preparation Wang Xiujuan;Xu Liping;Wang Min Journal of Capital Medical University    2007, 28 (2): 220-224.   Abstract （1045）      PDF（pc） （466KB）（1646）       Knowledge map    Save The manifestations of hepatotoxicity caused by Chinese medicinal herbs are similar with ordinary liver disease. Many pathological alterations of hepatotoxicity can be seen, such as hepatocellular damage, liver disfunction, increased serum transaminase, hepatomegalia, jaundice, cholestasis, chronic hepatitis complicated with fibrosis, hepatic cirrhosis、fulminating hepatic failure, liver tumor, and etc. In most cases, the liver damage is reversible after discontinuation. The commonly-seen herbs which may cause hepatotoxicity are Huang Yao Zi(Tuber Dioscoreae Bulbiferae)、Cang Er Zi(Fructus Xanthii Sibirici)、Lei Gong Teng(Radix Tripterygum)、Ku Lian Zi(Fructus Meliae Azedarach), etc., and the compound preparations are Zhuang Gu Guan JIe Wan(The Pill for Asthritis), Ke Yin Wan(The Pill for Psoriasis), Xiao Chai Hu Tang (Xiao Bupleuri Decoction), and so on. In addition, the improper combination of Western medication and Chinese medicinal herbs may also bring about hepatotoxicity. Except the toxicity of herbs themselves, the other factors include the dosage, time, the body constitution of patients, sensitivity, seasons, and geographic regions, etc. Therefore, the medicinal herbs and their preparations should be used rationally under the guidance of the theory of traditional Chinese medicine and differentiation of symptoms, and the medical skill should be improved, which are the effective measures for avoiding hepatotoxicity. Related Articles | Metrics

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Analysis of LI Ping;WANG Ju-sheng;ZHAO Jing-xia;WANG Ping;LIU Xin;ZHANG Guang-zhong;ZHOU Dong-mei Journal of Capital Medical University    2009, 30 (4): 413-417.   DOI: 10.3785/j.issn.1006-7795.2009.04.002 Abstract （1310）      PDF（pc） （1160KB）（1110）       Knowledge map    Save Psoriasis is one of the most common and gene-related human skin diseases. Traditional Chinese medical therapy has curative effect with fewer side effects, so the investigation of the rules of TCM differentiation and pharmacological treatment in psoriasis would provide us a new approach to improve its clinical practice. By document analysis, we proposed a hypothesis that the pathogenesis of psoriasis-'toxin accumulation in blood' means the disease happened in blood and its characteristic was 'toxin coming from excessive heat’. In addition, we elucidated the meaning of 'toxin accumulation in blood’ in the view of modern medicine, which might develop the TCM theory of 'treating psoriasis by modulating blood’. Related Articles | Metrics

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Research progress of psoriasis-like models DI Ting-ting;ZHAO Jing-xia;LI Ping Journal of Capital Medical University    2012, 33 (2): 275-279.   DOI: 10.3969/j.issn.1006-7795.2012.02.030 Abstract （1133）      PDF（pc） （1015KB）（2163）       Knowledge map    Save Lack of the naturally occurred psoriasis animal models once made the researches on human psoriasis phenotype and pathogenesis stagnated in last several years. But with the increasing understanding of psoriasis mechanism, a series of models has been explored at organic, cellular and molecular levels. We evaluated the current psoriasis models and analyze theirs advantages and limitations, to provide reference for psoriasis studying, drug screening and treatment. Related Articles | Metrics Cited: Baidu(2)

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Aortic arch reconstruction for acute type A aortic dissection Sun Lizhong, Rong Tianhua Journal of Capital Medical University    2015, 36 (3): 338-344.   DOI: 10.3969/j.issn.1006-7795.2015.03.002 Abstract （409）      PDF（pc） （1095KB）（431）       Knowledge map    Save Acute type A aortic dissection involving the aortic arch remains an inherently lethal medical condition ever since it is known to us. Prompt diagnosis and proper treatment is urgently needed and supposed to significantly lower the mortality rate. Although open surgical repair is undoubtedly the mainstream technique now, high rate of postoperative mortality and morbidity has always been a formidable challenge. Along with the rapid development of the aortic surgery and cognition of the disease, a variety of approaches have been invented or introduced, mostly aiming at simplifying procedure, minimizing surgical trauma and improving prognoses at the same time. Apart from the conventional surgical operation, recently emerged Sun's procedure, open branched stent graft placement, hybrid procedure, and even the endovascular repair have been taken into consideration. However, the more choices we have, the more we come to realize that ideal techniques with the characteristics of stability, convenience, riskless, effectiveness and wide applicability remain to be pursued. Because of the complexity of aortic arch in aspects of anatomy, function and pathological changes, the appropriate approach for patients with type A dissection involving the aortic arch remains controversial. This article provides current information about strategies of aortic arch reconstruction used for acute type A aortic dissection by reviewing related publications as well as brief discussions. Reference | Related Articles | Metrics

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The relationship between psychogenic erectile dysfunction of kidney deficiency type and attention network dysfunction Dong Linrui, Yan Bin, Feng Sitong, Ning Yanzhe, Feng Zhengtian, Jia Hongxiao Journal of Capital Medical University    2022, 43 (3): 393-397.   DOI: 10.3969/j.issn.1006-7795.2022.03.011 Abstract （247）      PDF（pc） （1050KB）（298）       Knowledge map    Save Objective To investigate the relationship between psychogenic erectile dysfunction (pED) of kidney deficiency type (KD) and attention network dysfunction. Methods A total of 26 patients with pED of KD type and 24 were recruited from Xiyuan Hospital of China Academy of Chinese Medical Science from March 2021 to January 2022. And 24 healthy males were recruited as the control group according to the principle of matching between groups in terms of age, sex and years of education.Both study groups underwent attention network test (ANT). Results Compared with healthy subjects, the patients with pED of KD type showed significantly poorer efficiency on executive control network and overall mean reaction time (P<0.05). The alerting network efficiency, orienting network efficiency and mean correctness rates were not statistically significant compared to normal control subjects (P>0.05). Furthermore, efficiency on executive control network was positively associated with the scores of kidney yang deficiency(r=0.408,P=0.039).And the multi-factor Logistic regression analysis showed efficiency on executive control network was positively associated with pED of KD type (P<0.05). Conclusion Our findings suggested that patients with pED of KD type exhibited impairments of executive control network, which may be related to altered neural activities in brain regions associated with executive control functions. It provided a modern scientific basis for the treatment of psychogenic erectile dysfunction of kidney deficiency type by Chinese medicine theory of kidney. Reference | Related Articles | Metrics

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Role of mitochondrial deacetylated protein SIRT3 on the cochlea of noise-induced hidden hearing loss Yang Zijing, Zhao Chunli, Liang Wenqi, Chen Zhongrui, Liu Ke, Gong Shusheng Journal of Capital Medical University    2022, 43 (4): 521-526.   DOI: 10.3969/j.issn.1006-7795.2022.04.002 Abstract （296）      PDF（pc） （5583KB）（338）       Knowledge map    Save Objective To investigate the role of mitochondrial deacetylation protein sirtuin-3 (SIRT3) in noise-induced hidden hearing loss (NIHHL). Methods Injected SIRT3 inhibitor [3-(1H-1,2,3-triazol-4-yl) pyridine, 3-TYP] and untreated C57BL/6J mice were exposed to 100 dB white noise for 2 hours and hearing examination was performed within 24 h or fourteen days after noise exposure (NE). The changes of ribbon synapses (RS) of inner hair cells (IHCs) were observed by immunofluorescence staining. Via the frozen section, 4-hydroxynonenal (4HNE) staining was used to observe the accumulation of reactive oxygen species (ROS) in the cochlea. Results Compared with the control group, the NE group and 3-TYP group showed a temporary threshold shift, ROS accumulation and loss of ribbon synapses after NE. Compared with the NE group, the threshold of mice in 3-TYP group did not return to normal level 2 weeks after NE. We also found an obvious loss of ribbon synapses and the accumulation of ROS. Conclusion NE causes oxidative stress in the inner ear, and SIRT3 may protect auditory system function by resisting oxidative stress. Reference | Related Articles | Metrics

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Establishment of Animal Model of Human Cervical Cancer in BALB/c Nude Mice by Tumor Tissue Xenograft Zhang Kaiju;Zhao Yanzhong;Shang Hongwei;Kong Lu;Zhang Yuxiang Journal of Capital Medical University    2008, 29 (5): 593-596.   Abstract （1646）      PDF（pc） （576KB）（1685）       Knowledge map    Save Objective To establish the human cervical cancer animal model through abdominal subcutaneous transplantation in BALB/c nude mice and investigate the rate of tumor-forming and the biological features of the tumor.Methods Human cervical cancer tissue derived from surgical specimens were transplanted into the subcutis of nude mice.The rate of tumor transplantation,generic characteristic,tumor growth of bearing cancer mice were observed every day.On day 85 the tumor-bearing mice were killed and tumor masses were collected for analysis of histological features.Genomic DNAof tumor tissue,peripheral blood,liver,spleen,kidney,omentum,and uterus annex of tumor-bearing BALB/c nude mice were extracted,and then using all organs' genomic DNAas templates,we detected the HPV DNAexpression with polymerase chain reaction(PCR).Results In this experiment,the delitescence period of tumor-forming were 30～35 days.On day 42 the tumor tubercles were visible and grew fast day by day.The average tumor-take rate was 90.5%,and the mean tumor surface areas was(50.0±5.1)mm2 on day 80.The transplanted tumors grew well by local invasion.Metastasis was not found.The tumors were analyzed by HEstaining,and the histological appearance of the tumors before and after transplantation were very similar.The positive rate of HPV DNAin the tumor tissue was 100%.The appearance of HPV DNAbefore and after transplantation was the same.The PCRresults definitely displayed the subtype of high-risk human papillomavirus,which suggested cervical cancer patient's HPV16 infection,not HPV18 infection.But HPV DNAwas not detectable in peripheral blood,the spleen,the liver,the kidney,the omentum,and the uterus annex of tumor-bearing BALB/c nude mice.Conclusion Human cervical cancer model in nude mice has been successfully established which simulates the biological features of human cervical cancer.The animal model of human cervical cancer in BALB/c nude mice exhibit a high rate of tumor transplantation,and which may provide a convenient and ideal tool for the research of the mechanism and therapy of human cervical cancer. Related Articles | Metrics Cited: Baidu(4)