Immunosuppressive Effects of Triptonide on Allergic Contact Dermatitis in Mice and the Study of its Mechanism

Journal of Capital Medical University ›› 1996, Vol. 17 ›› Issue (1): 52-54.

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Immunosuppressive Effects of Triptonide on Allergic Contact Dermatitis in Mice and the Study of its Mechanism

Zhou Ping¹, Chen Xuerong², Li Shiyin²

1. Department of Dermatology, Anzhen Hospital, Capital University of Medical Sciences;2. Dcpurtment of Dermatology, The Third Hospital, Beijing Medical University

Received:1995-01-06 Revised:1900-01-01 Online:1996-01-15 Published:1996-01-15

Abstract

Abstract: Triptonide (Tri)extracted from Tripterygium wilfordii Hook inhibited the proliferation of mouse splenocytes induced by suboptimal concentration of concanavalin A or Lipoplysaccharide at concentrations of 0.02, 0.10,and 0.50 mg/L.Although allergic contact dermatitis to dinitrofluorobenzene (DNFB) was inhibited by Tri 1.0, 2.0,and 5.0 mg/kg(ip,qd×5d),the splenocyte interleukin-2 secretion activity of these mouse was not suppressed.The data indicates that Tri has suppressive effects on mouse immune functions and may be used as a potent immunosppressive agents.

Key words: triptonide, allergic contact dermatitis, lymphocytes, interleukin-2, mice

CLC Number:

R758.22

Zhou Ping;Chen Xuerong;Li Shiyin. Immunosuppressive Effects of Triptonide on Allergic Contact Dermatitis in Mice and the Study of its Mechanism[J]. Journal of Capital Medical University, 1996, 17(1): 52-54.

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Immunosuppressive Effects of Triptonide on Allergic Contact Dermatitis in Mice and the Study of its Mechanism

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