Abstract: Objective To study the expression of gelatinases in malignant and benign ovarian epithelial tumor.Methods We use gelatinases methods to investigate serum of 20 cases malignant ovarian epithelial tumor and 18 cases benign ovarian epithelial tumor.Results The active MMP-2 protein in malignant ovarian epithelial tumor and benign ovarian epithelial tumor was(140322)±(10324.8) and(110657.9)±759.4,respectively.The difference in the intensity(P<0.05) was statistically significant. The active MMP-9 protein in malignant ovarian epithelial tumor and benign ovarian epithelial tumor was(280822.1)±(20739.9) and(220081.9)±(10924.4),respectively.The difference in the intensity(P<0.05) was statistically significant.Conclusion The expression of active MMP-2,-9 protein in malignant ovarian epithelial tumor was higher that that in benign ovarian epithelial tumor.

Key words: malignant ovarian epithelial tumor, benign ovarian epithelial tumor, gelatinases, serum