Exprimental Study on Foxp3 mRNA Expression in the Peripheral Blood Monocyte of Mice with Allergic Rhinitis

Journal of Capital Medical University ›› 2009, Vol. 30 ›› Issue (1): 49-53.

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Exprimental Study on Foxp3 mRNA Expression in the Peripheral Blood Monocyte of Mice with Allergic Rhinitis

Xi Lin^1,2, Han Demin^1,2, Fan Erzhong^1,2, Li Ying^1,2, Jin Shanzhe^1,2, Zhang Wei^1,2, Zhang Luo^1,2

1. Department of Otolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University,;2. Beijing Institute of Otolaryngology, Key Laboratory of Otolaryngology Head and Neck Surgery, Ministry of Education

Received:2008-11-18 Revised:1900-01-01 Online:2009-02-21 Published:2009-02-21

Abstract

Abstract: Objective To investigate the level of transcription factor Foxp3 rhinitis level in the peripheral blood monocyte(PBMC)of mice with allergic rhinitis, and its relationship with pathogen of allergic AR. Methods 30 female BALB/c mice were divided into 2 groups:ovalbumin(OVA)group and control. After 21 days the AR models were established. The pathological differences between the two groups were then surveyed. Reverse transcription-polymerase chain reaction(RT-PCR)was used to examine Foxp3 mRNA expression in the spleen PBMC from the two groups. Results In contrast to the control, OVA models had significant pathological changes in the nasal cavity, including epithelial damage and eosinophil infiltration in the submucosa. Foxp3 mRNA expression was lower in subjects with AR than that in the controls(P<0.05). Conclusion The expression of Foxp3 mRNA in the OVA group is low which suggests that Foxp3 may play an important regulatory role in the pathogenesis of AR.

Key words: allergic rhinitis, Foxp3, regulatory T cells, peripheral blood monocyte

CLC Number:

R 765.21

Xi Lin;Han Demin;Fan Erzhong;Li Ying;Jin Shanzhe;Zhang Wei;Zhang Luo;. Exprimental Study on Foxp3 mRNA Expression in the Peripheral Blood Monocyte of Mice with Allergic Rhinitis[J]. Journal of Capital Medical University, 2009, 30(1): 49-53.

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Exprimental Study on Foxp3 mRNA Expression in the Peripheral Blood Monocyte of Mice with Allergic Rhinitis

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