Abstract: Objective To study the relationship between diabetic nephropathy(DN) and its risk factors. Methods A total of 381 type-2 diabetic patients were divided into three groups: normal albuminuria(NA), microalbuminuria(MA) and clinical proteinuria(CP), depending on the levels of urinary albumin excretion rate(UAER). The differences of the 3 groups in terms of age, duration of diabetes, systolic blood pressure(SBP), diastolic blood pressure(DBP), waist-to-hip ratio(WHR), body mass index(BMI), fasting plasma glucose(FPG), glycosylated hemoglobin A1c(HbA1c), triglyceride(TG), total cholesterol(TC), high-density lipoprotein cholesterol(HDL-C), low density lipoprotein cholesterol(LDL-C), uric acid(UA) and C-peptide. Logistic regression analysis was used to analyze the possible factors that might affect the DN. Results There were statistically significant differences in age, duration of diabetes, WHR, SBP, DBP, LDL-C, TC, HbA1c C-peptide and UA among the 3 groups. Logistic regression analysis showed that diabetic duration and SBP were independent risk factors(OR=1.029 and 1.088, P<0.05 for both). Conclusion A close correlation has been found between duration of diabetes and SBP. Monitoring and evaluating systemic factors will be helpful for prevention and treatment of DN.

Key words: type-2 diabetes, diabetic nephropathy, risk factors