Progresses in studies on novel biomarkers for early diagnosis of diabetic nephropathy

doi:10.3969/j.issn.1006-7795.2017.02.001

Abstract

Abstract: Diabetic kidney disease (DKD) as a common and severe chronic complication of type 2 diabetes mellitus (T2DM) has rapidly become an important public health problem. It can be reversed in early stage after treatment, or become end-stage renal disease in advanced stage. Therefore, early diagnosis and prediction of DKD for clinical treatment is particularly important. Although microalbuminuria (MAU) is an early marker for kidney damage in type 2 diabetes mellitus, its predictive value is now questioned. In recent years, it was found that proteomics may become a new tool in the diagnosis of diabetic nephropathy. Haptoglobin (HP) as an acute phase protein with a variety of functions was found may be closely related to the occurrence and development of diabetic nephropathy. Therefore, this article reviewed the progress on research of haptoglobin with the pathogenesis of diabetic nephropathy.

Key words: diabetic nephropathy, microalbuminuria, haptoglobin

CLC Number:

Song Lini, Liu Jingyi, Zhang Yichen, Cao Xi, Yuan Mingxia, Yang Jinkui. Progresses in studies on novel biomarkers for early diagnosis of diabetic nephropathy[J]. Journal of Capital Medical University, 2017, 38(2): 145-150.

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