Non-synonymous variant rs2228145 in interleukin-6 receptor (IL-6R) gene is associated with allergic rhinitis in Chinese subjects

doi:10.3969/j.issn.1006-7795.2017.05.013

Abstract

Abstract: Objective Allergic rhinitis (AR) is a complex chronic inflammatory disease of the nasal mucosa, caused by an interaction between genetic and environmental factors. As evidence suggests that a proportion of individuals with AR also present symptoms of asthma and some genetic variants may have increased susceptibility to both AR and asthma. The objective of this study was to identify whether asthma susceptibility variant rs2228145 in interleukin-6 receptor (IL-6R) is associated with AR in the Chinese population. Methods A cohort of 402 individuals with physician diagnosed AR and 416 healthy controls were recruited from the Han Chinese population in Beijing. DNA was extracted from the peripheral blood. rs2228145 was genotyped using the sequenom mass array technology platform. Results Analysis of frequency differences of allele between the AR patients and control subjects showed that rs2228145 in IL-6R was significantly associated with AR (P=0.0039,P_corrected=0.001 6). Genotype analysis further confirmed the difference in distribution of this variant between AR patients and controls in both the co-dominant (P_{A/C vs A/A}=0.000,OR_{A/C vs A/A}=0.546,95%CI:0.389-0.766)and dominant (P_{A/C+C/C vs A/A}=0.001,OR_{A/C+C/C vs A/A}=0.575,95%CI:0.418-0.790) models. Conclusion These results suggest that the rs2228145 in IL-6R gene is associated with decreased risk for AR.

Key words: allergic rhinitis, asthma, interleukin-6 receptor, association studies

CLC Number:

R765

Zhao Yali, Zhang Yuan, Wang Chengshuo, Zhang Luo. Non-synonymous variant rs2228145 in interleukin-6 receptor (IL-6R) gene is associated with allergic rhinitis in Chinese subjects[J]. Journal of Capital Medical University, 2017, 38(5): 695-699.

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URL: https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/10.3969/j.issn.1006-7795.2017.05.013

https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/Y2017/V38/I5/695

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