Abstract: 24 patients with diabetic nephropathy were treated with piperazine ferulate. Changes in the amount of proteinuria within 24 h, the levels of serum creatine(Scr)and blood urea nitrogen(BUN)and hemorrheological parameters were measured. After 3 months'treatment,the amount of proteinuria decreased from 3.84±l.70 to l.80±0.89 g/24 h(P<0.01. Among them six cases of nephrotic syndrome were found,and their proteinuria decreaced from 6.48t±0.84 to 2.42±0.71 g/24 h(P<0.001),Scr levels(μmol/L)were reduced from 281±183 to 185±104(P<0. 05),whole blood viscosity levels were reduced from 6.64±0.42 to 6.18±0.51, plasma viscosity levels from 2.48±0.17 to l.96±0.11(P<0.05~0.01,and plasma fibrinogen levels(g/L)decreased from 4.68±l.17 to 3.95±0.98(P<0.05). It was shown that the effects of decreasing whole blood and plasma viscosity,lowering fibrinogen level,decreasing proteinuria and improving renal function were noted after treatment with this medication. Based on the above observation,piperazine ferulate has certain effects in the treatment of diabetic nephropathy.

Key words: diabetic nephropathy, platelet aggregation, hypercoagulability