The Effects of Mifepristone on Mouse Oestrous Cycle

Abstract

Abstract: The antiprogesterone mifepristone(RU486)was utilized for evaluating the effects on mouse oestrous cycle.Each mouse was injected into abdominal cavity with 1 mL RU486(2.5 mg/mL)(as experimental group)or 1 mL distilled water(as control group)respectively at the diestrus.After injection,the average days of oestrous cycle in animals of the experimental group changed from 5.3 to 11.2 d, whereas varied from 4.9 to 5.1 d in the control group.The changes of the length of the diestrus, proestrus and estrus were not clear,but the elongation of the metestrus was significant.These results showed that RU486 might exert some influences on the formation and regression of the corpus luteum.

Key words: mifepristone, mice, oestrous cycle

CLC Number:

Q492.5

Zhu Dingshou;Xu Qing;Weng Jing. The Effects of Mifepristone on Mouse Oestrous Cycle[J]. Journal of Capital Medical University, 1995, 16(2): 99-101.

[1]	Xu Longwei, Wang Yadan, Zhou Minsi, Wu Jing. Analysis of infiltration of neutrophils and macrophages in tissues of eosinophilic gastroenteritis mice [J]. Journal of Capital Medical University, 2025, 46(2): 306-313.
[2]	Liu Wei, Wang Jingyi, Zheng Xi, Han Yue, Li Wenxiong, Zhang Jin. Establishment and evaluation of Pseudomonas aeruginosa-induced sepsis model in mice [J]. Journal of Capital Medical University, 2025, 46(2): 324-332.
[3]	Wang Xiangdong, Jiang Min, Wang Xin, Gong Yongfeng. The role of glucocorticoid receptor in ischemia-reperfusion-induced kidney injury [J]. Journal of Capital Medical University, 2022, 43(2): 260-268.
[4]	Meng Xia, Li Meng, Wang Jingjing, Zhang Jing, Chen Baian, Lu Jing. Similarities and differences of cerebral β-amyloid protein characteristics between 5xFAD transgenic mice and alzheimer's disease patients [J]. Journal of Capital Medical University, 2022, 43(1): 106-112.
[5]	Ma Denglei, Li Yanzheng, Zhu Yanqiu, Li Lin, Zhang Lan. Effects of cornel iridoid glycoside on the behavioral and pathological changes on senescence-accelerated mouse prone 8 [J]. Journal of Capital Medical University, 2021, 42(5): 754-760.
[6]	Gao Lifang, Gao Wen. Antioxidant activity of lycopene-curcumin combination in mice with acute ethanol oxidative damage [J]. Journal of Capital Medical University, 2021, 42(1): 89-93.
[7]	Wang Aiting, Yan Dan, Qi Xianrong. Evaluation of the inhibitory effect of docetaxel-loaded polymeric micelles on breast cancer metastasis in mice [J]. Journal of Capital Medical University, 2020, 41(2): 225-230.
[8]	Wang Yuejiao, Ruan Xiangyan, Gu Muqing, Cai Guiju, Li Xue, Zhang Lingyan, Alfred O. Mueck. Tamoxifen treated breast cancer xenograft in nude mice and uterine pathological changes [J]. Journal of Capital Medical University, 2019, 40(4): 539-543.
[9]	Xu Qing, Liu Lina, Song Yanting, Qu Aijuan. Assessing stiffness of carotid artery via two-dimensional speckle-tracking in mice [J]. Journal of Capital Medical University, 2018, 39(6): 883-888.
[10]	Xiao Luyao, Zhang Jie, Zheng Shuai, Mei Shaoshuai. Effects of pH values and doses on intraperitoneal injection of L-arginine induced acute pancreatitis in mice [J]. Journal of Capital Medical University, 2017, 38(5): 700-703.
[11]	Chen Bin, Liu Wei, Shi Zhiguo, Liu Tao, Zheng Hui. Impact of sevoflurane and high concentration of oxygen on expression of caspase-3 and cognition of aged mice [J]. Journal of Capital Medical University, 2017, 38(3): 348-351.
[12]	Gao Lifang, Luo Kui, Cui Shuxiang. Hepatoprotective effects of dietary 5'-nucleotide on nonalcoholic liver injury in mice [J]. Journal of Capital Medical University, 2016, 37(3): 356-359.
[13]	Zhu Shengtao, Sun Xiujing, Li Peng, Guo Qingdong, Zhu Shengquan, Zhang Shutian. Effect of PHF8 gene on the growth of transplanted tumor of esophageal squamous-cell carcinoma in nude mice [J]. Journal of Capital Medical University, 2016, 37(1): 12-16.
[14]	Bao Xunjie, Cai yanning, Zhu Yanqiu, Yang Cuicui, Li Lin, Zhang Lan. Promoter methylation analysis of seven clock genes in the brain of 3xTg mice [J]. Journal of Capital Medical University, 2015, 36(6): 875-881.
[15]	Liu Yingxin, Zou Dawei, Geng Jianguo, Gao Yanbin, Shang Yawen, Li Jiaoyang, Gong Muxin, Peng Qizhen. Effects of tangshenning on HGF expression of renal tissue in type 2 diabetic KK-Ay mice [J]. Journal of Capital Medical University, 2015, 36(5): 747-750.

The Effects of Mifepristone on Mouse Oestrous Cycle

PDF

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments