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    15 January 1997, Volume 18 Issue 1
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    论著
    Distribution of Progesterone Receptorin Uterus of Mouse and Its Relation with Blastula Implantation
    Zhu Dingshou;Liang Yuanjing;Xu Qing;Weng Jing;Shi Xiaolin;Lu Xin
    1997, 18(1):  1-3. 
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    Immunocytochemical LSAB methods were used to show changes of progesterone receptor in endometrium.We found that progesterone receptor located in the nucleus of uterine endometrium cell,stroma cell and smooth muscle cell,but not in their cytoplasma.During disestrus the uterine muscular cell and endometrium cell showed positive reaction (1+).There was no difference between them.In estrus,the endometrial cell and gland epithelium showed comparatively strongly positive result(1.5+),but muscular cell remained the same.The results indicated that progesterone receptor play an important role in the preparation of blastula implantation.
    Comparation of Three Methods for theDetection of Human Papillomavirus DNAin Paraffin embedded Tissues of Cervical Squamous Intraepithelial Lesions
    Ma Yaluan;He Cuizhen;Yao Qingying;Qi Yahui;Wang Xin;Gao Tianxiang
    1997, 18(1):  4-7. 
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    In order to compare the sensivity of three methods for the detection of human papillomavirus (HPV)16 DNA, in situ hybridization (ISH), in situ hybridization after amplification by polymerase chain reaction (IS-PCR) and polymerase chain reaction (PCR) were performed in paraffin embedded tissues of 39 cervical squamous intraepithelial lession (SILs). The results showed the detective rate of HPV DNA16 by ISH was 46.2% (17/39).It was lower than 66.7%(26/39) by IS-PCR (P<0.05), and significantly lower than 84.6%(33/39) by PCR (P<0.01). Using conventional ISHwith a dig labbeled probe,variable numbers of superfical cells in SILs showed detectable HPV DNAwhen in situ assay was performed after amplification,increased numders of superfical cells had detectable HPV16 DNA and the signals of hybridization were much more intense.PCR method showed the highest sensitivity,but it failed to show the precise localization of intracellular HPV16 DNA.

    Quantitative Studies of Morphologic of Pathology on the Thrombolytic Effect of Mai Tong Ling No.1
    Chen Tiejun;Chen Ruifen;Zhou Yijian;Li Nan
    1997, 18(1):  8-11. 
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    Animal model of the femoral artery thrombosis was produced in rabbits. Quantitative morphologic changes were traced during the thrombosis from 1 to 6 d .Mai Tong Ling No.1 was administered through gastric tube [5 mL/(kg·d)].The results showed that: Mai Tong Ling No.1 may defer thrombsis process and promote the dissolution of the thrombus through leucocyte increase in the thrombus.

    论著
    Quantitative Determination of the Nuclei of Squamous Carcinoma Using Image Analysis Instrument
    Wen Xiangyun
    1997, 18(1):  12-14. 
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    Quantitative determination of the size,figure and color of neoplastic cell nuclei and comparison with those of the normal cells were performed using image analysis instrument.The result showed that the nuclei of squamous carcinoma have prominent difference with normal cell nuclei.So, the image analysis method can afford much quantitative data of neoplastic cell nuclei and is valuable for diagnosing such cancer.
    Experimental Study on the Antiaging Effect of Cordyceps Sinensis Cultivated by Artificial Fermentation
    Kong Xianghuan;Wang Hong;Xiao Zhongxin;Chu Jinhua;Yin Xuejun;Yang Xinghua
    1997, 18(1):  15-17. 
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    The antiaging effect of artificially fermented Cordyceps sinensis (AFCS) was studied in vitro .The result showed that the LPO product in homogenate of rat liver was inhibited markedly by the juice of Cordyceps sinensis in vitro with dose response effect;the LPO product in liver homogenate of mouse decreased significantly and the activity of SOD in erythrocyte of mouse increased significantly.These results implied that AFCS has an obvious antiaging effect.
    Studies on the Effect of Chinese Medicine on Fluidity of Membrane Lipids
    Yan Shulian;Zhang Jinnan
    1997, 18(1):  18-20. 
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    The present paper discusses the Chinese medicine in protection of fluidity of membrane lipids from damage of human erythrocyte by superoxide anion(O2·-) generated from autooxidation of pyrogallie acid at pH8.4. The result indicates that some Chinese medicine have evident and different level protection for erythrocyte membrane.
    A Morphological and Cytochemical Study on Testes of Rats with Experimental "Spleen Deficiency" Syndrome
    Xu Qing;Lu Xin;Shi Xiaolin;Wang Xiuqin;Shang Hongwei
    1997, 18(1):  21-24. 
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    Twenty adult Wistar rats were used and divided into two groups,i.e.normal control group and experimental "spleen deficiency" group.The experimental rat had been fed with the decoction of Dahuang.The animals of both groups were killed simultaneously 42 days la ter ,the testes of each animal were studied morphologically and cytochemically.The results of morphological observation in experimental "spleen deficiency" group showed: ①The volume of testis had shrunk.②The seminiferous tubules had changed into irregular shape.③The diameter had shrunk.④The wall had become thinner.⑤The intercellular substances became edematous. The reactivity of SDH, ALP, ACP, ATPase of spermatogonic cells in experimental "spleen deficiency" group showed definite changes on cytochemistry. The reactivity of 3-β-HSDH in interstitial cells was weaker than normal control group. This study demonstrated not only that the function of digestive system became lowered,but also the reproductive system underwent pathological changes.

    The Morphological and Cytochemical Study on Adrenal Glands of Rats with Experimental "Splenic Deficiency" Syndrome
    Ji Fengqing;Wang Xiuqin;Shi Xiaolin;Lu Xin;Xu Qing
    1997, 18(1):  25-28. 
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    Twenty adult wistar rats were used and divided into two groups,normal control group and "experimental splenic" deficiency group. The experimental rats had been fed with the decoction of Dahuang for 42 d with ensuing experimental "splenic deficiency" symptom.The adrenal glands of two groups were observed morphologically and cytochemically.The resulted morphological study of experimental "splenic deficiency" group indicated that the zona glomernlosa became narrower, the stains in every zones were light, the cytoplasm were vesicular vacuolated, the cell interstitium became wider. The cytochemical study showed that activity of every enzyme in cortex and medulla of adrenal glands changed in various degrees and ACP, ATPase showed definite changes.This research proved that "splenic deficiency" syndrome resulted in not only that the function of digestive system became lowered, but also that the adrenal gland underwent pathological changes.

    论著
    Role of Endothelin in Rat Abdominal Aortic Thrombolysis
    Tang Yi;Yao Xinghai;Tang Chaoshu
    1997, 18(1):  29-32. 
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    Using a rat abdominal aortic thrombosis model induced by directcurrent-ferric trichloride method, we found that plasma ET level was 3.7 times as baseline after lysing the thrombus with urokinase 250000 units per kilogram, while 5 microgram per kilogram of exogenous ET prolonged the time of thrombolysis,which was 115% of baseline,meanwhile plasma ET was 6 times as baseline.Incubation of rat aortic strip in vitro showed that 20 mmol/L of taurine had no effect on base ET release,but it inhibited the stimulation of thrombin and A23187 to ET in a dose dependent way.Plasma ET had 17% and 40% of decrease in vivo after injection of taurine,and it required a 45% shorter time to lyse the thrombus.We conclude that ET inhibits thrombolysis,its abnormally increasing can be weakened by taurine which is benificial to thrombolysis.
    A Preliminary Clinical Trial on Mycobacterial Polysaccharides in Treatment of Rheumatoid Arthritis
    Zuo Dapeng;Wang Qiuping;Zhang Jingxiu;Chen Ren;Zhang Zezheng
    1997, 18(1):  33-36. 
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    50 patients with active rheumatoid arthritis who have no improvement after twomonths' treatment with NSAIDs were divided into two groups randomly. One group accepted the treatment of MPS plus NSAID.While another group accepted the treatment of MTX plus NSAID. The clinical result and the effect on patient's immune fuction had been evaluated after six months' treatment.Then the treating programs in the two groups were exachanged and continued for another six months. Once again the result and the effect were appraised . At the same time, the adverse reactions of MPS and MTX were observed. The results of the oneyear's study showed that the total effective rate was 48% in the group of MPS plus NSAID, but 60% in the group of MTX plus NSAID. Howere there was no statistical significant difference between the two groups. The observation of the side effects showed that it was 3.8% in the MPS group,but 32% in the other.The patients' CD3 and CD4 Tlymphocytes in peripheral blood decreased after the use of MTX, denoting that the immune function was suppressed. But by using MPS, both CD3 and CD4 can be regulated in two ways.This study shows that MPS can be used in the treatment of rheumatoid arthritis.
    A Clinic Study of Mycobacterial Polysaccharides on Treatment of Bronchial Asthma
    Lu Jixian;Wang Jianjun;Liu Fuqiang;Ye Zhiming;Zhang Jinyou;Wang Jinjin;Chen Hailun;Chen Ren
    1997, 18(1):  37-40. 
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    cell subgroup,IgG4,IgE,sIL-2R,ACTH and cortisol in 52 patients peripheral blood with bronchial asthma onset phase,as well as 50 controls were measured.The levels of IgG4,IgE,sIL-2R and ACTH in asthma patients were significantly higher compared to those of controls.The results suggest abnormality of cell immunity and endocrinic function in asthma onset phase.52 patients were divided into 2 groups,32 were treated with MPS,20 with regular therapy.The values of CD4+/ CD8+ in 32 patients after treatment with MPS greatly increased and the levels of IgG4,sIL-2R decreased,but ACTH,cortisol did not change.
    The Influence of Primary Sjogren's Syndrome on Respiratory System
    Li Xiaoxia;Xu Wenbing;Zhu Yuanjue;Tan Fulin;Ma Yi
    1997, 18(1):  41-44. 
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    In conjunction with clinical symptoms, chest-Xray and pulmonary function,the pulmonary manifestations in 108 cases of primary SS were analysed with resultant injury of respiratory system in 57 cases, accounting for 52.8%, indicating that involvement of respiratory tract was of frequent occurrence in for this disease . The comparison of pulmonary function betweem patients with normal and abmormal chest X-ray revealed no significant difference, suggesting that damage of pulmonary function could not be excluded even when SS atients showed no respiratory symptom or no abnormal finding in chest X-ray. So the possibility of SS should be suspected of when interstitial lung desease was detected, so the chest X-ray and pulmonaty function examination should be taken as a routine performance in SS patients for early detection of pulmonary damage.
    Studies on Serum Lipoprotein Lipids and Apolipoproteins and Insulin Secretion in Simple Obese Children
    Hua Qi;He Shida;Wang Yuqin
    1997, 18(1):  45-47. 
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    To study the initial period of fat deposition in human obesity,27 children of over 120% ideal body weight aged 8～12 years old and 18 children of ideal body weight in the same age were observed.It was found that TC,TG,Ox-LDL and apoBwere markedly higher and apoA lower in obese children group than in control group (P<0.05～0.001),there were no difference between two groups in Lp(a).Abdominal ulfrasonic examination showed that 92.6% obese children had fatty liver.It was also found that peptide Cand insulin were higher in obese children group than in control group (P<0.05 and 0.001),and on positive correlation existed between peptide Cand body weight and between insulin and body weight.The investigation results suggested that there were abnormal metabolism of fatty and glycerol in simple obese children.
    The cGMP Level of Gastric Mucosa, Gastric Juice and Plasma in Patients with Upper Alimentary Diseases
    Zhang Yicheng;Wang Di;He Yina
    1997, 18(1):  48-51. 
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    The cGMP level of gastric mucosa,gastric juice and plasma in the healthy adults as well as in patients with upper alimentary diseases were assessed by RIA .The results showed that the cGMP level in gastric mucosa and plasma of patients with gastric carcinoma, gastric ulcer were significantly higher than in normal subjects( P <0.01), but in gastric juice no difference could be detected.
    The Histopathologic Observation and Analysis for Intracranial Saccular Aneurysms
    Zhao Tongjian;Cao Shijian;Liu Hui;Li Jingjun
    1997, 18(1):  52-55. 
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    Eighteen cases of intracranial saccular aneurysms were studied histopathologically using special stain and immunohistochemical anethods.The results showed that the basic histopathologic changes of saccular aneurysms included damage, degeneration and repair. The primary kinetic force producing an aneurysm originated from an pressure exerting on the arterial wall by changed velocity of blood flow. The larger blood vessel and the stronger repairing ability of the organism were bases for forming large aneurysms. The middle and small aneurysms had frequently the chance of rupture and hemorrhage in wall of aneurysm. The production and development of aneurysms can be influenced by acquired factors. This study is of clinical value for affording some hints for the mechanigm of such aneurysms and their prevention and treatment.

    论著
    Serum Calcium regulating Factors Levels in Women with Normal Pregnancy and with Pregnancy Inoluced Hypertension
    Chi Guizhu;Li Longmin;Rao Xiaoxue;Tie Liping
    1997, 18(1):  56-58. 
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    Seven items of serum idices related to calcium regulation were measured in 145 normal pregnant women (with different gestation periods and at postpartum stage), 90 cases with moderate and severe PIH and non pregnant women.Some of them were given calcium supplement from 2nd trimester to term.Serum calcium,phosphorus,alkaline phosphatase,thyroxine calcitonin,D3[25(OH)D3],and osteocalcin were measured in 1st,2nd,3rd trimester and after delivery. PIH morbidities were compared between calcium supplement and no supplement .Results showed that each index was increased with the increase in gestation week and at postpartum stage in normal pregnancy, but not in PIH.Calcium supplement in 2nd trimester reduced the PIH morbidity significantly.Calcium deficiency could increase PIH morbility and calicium supplement from 2nd trimester could reduce the PIH morbidity.
    Susceptibility of Genetic Aminoglycoside-induced Hearing Loss
    Zhu Xiaonong;Liu Wei;Fen Yan;Fan Erzhong;Lian Nengjing;Xia Wenru;Zhao Xiaoyan;Wang Hong;Kong Fanhua;Liu Donglin;Chen Ren
    1997, 18(1):  59-63. 
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    We notice that the aminoglycoside induced hearing loss often happens with an obviously high familial susceptibility, showing a mother to child genetic phenomenon. To find the immunogenetic mechanism of this disease,we chose 8 affected kindreds, in each of which there was no blood relationship between father and mother, to test the family members'HLA types. The linkage analysis (with Lods Method), haploid analysis and affected sib pairs analysis were done after the typing. The results suggest that the gene(s) which affects the susceptibility of antibiotic induced hearing loss is possibly linked with the HLAgenes and is inherited according to a model of autosomal dominant inheritance.

    论著
    Clinical Characteristics Analysis of Acute Inferior Wall Myocardial Infarction
    Xing Chengyi;Chen Bingliang;Meng Qingyi
    1997, 18(1):  64-67. 
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    Characteristics of acute inferior wall myocardial infarction were analysed in 120 patients.The results showed that the diseased right coronary artery related highly to the acute inferior myocardial infarction,while the proximal lesion of right coronary artery related highly to the right ventricular involvement.In term of the electrocardiographic features, the case with anterior ST segment elevation frequently associated with right ventricular infarction (42.9%,12/28)and that with anterior ST segment depression frequently with lateral posterior wall infarction (54.9%,28/51).The results also showed that cases with right ventricular and/or lateral posterior wall infarction were apt to have a worse prognosis.
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